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A new view to intracellular pathogens and host responses in the South of Spain
EMBO Mol Med. 2012 Mar;4(3):160-4 García-del Portillo F , Cossart P. A workshop on ‘ The Biology of Intracellular Bacterial Pathogens ’ was held last October in a venue of the International University of Andalusia (UNIA) located in the World Historic...
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The antibiotic resistome: challenge and opportunity for therapeutic intervention
Future Med Chem. 2012 Mar;4(3):347-59 Martinez JL . Despite the relevance of infectious disease as main causes of human morbidity and mortality, the development of new antibacterials is not among the highest priorities for pharmaceutical companies....
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Balancing noise and plasticity in eukaryotic gene expression
BMC Genomics 2012, 13:343 Bajic D, Poyatos JF . Coupling the control of expression stochasticity (noise) with the ability of expression change (plasticity) can constrain gene function and limit adaptation. Several factors, such as transcription...
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WIP: WASP-interacting proteins at invadopodia and podosomes
Eur J Cell Biol. 2012 Jul 21 García E, Jones GE, Machesky LM, Antón IM . Regulated cell invasion resulting from migratory and matrix-degrading events is an essential step in physiological processes such as the inflammatory response and tissue repair....
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Host proteolytic activity is necessary for infectious bursal disease virus capsid protein assembly
J Biol Chem. 2012 Jul 13;287(29):24473-82 Irigoyen N, Castón JR , Rodríguez JF . In many viruses, a precursor particle, or procapsid, is assembled and undergoes massive chemical and physical modification to produce the infectious capsid. Capsid...
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The role of capsid maturation on adenovirus priming for sequential uncoating
J Biol Chem. 2012 Jul 12 Perez-Berna AJ, Ortega-Esteban A, Menendez-Conejero R, Winkler DC, Menendez M, Steven AC, Flint SJ, de Pablo PJ, San Martín C . Adenovirus assembly concludes with proteolytic processing of several capsid and core proteins....
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Latest insights on adenovirus structure and assembly
Viruses. 2012 May;4(5):847-77 San Martín C . Adenovirus (AdV) capsid organization is considerably complex, not only because of its large size (~950 Å) and triangulation number (pseudo T = 25), but also because it contains four types of minor proteins...
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Cryphonectria nitschkei virus 1 structure shows that the capsid protein of chrysoviruses is a duplicated helix-rich fold conserved in fungal double-stranded RNA viruses
J Virol. 2012 May 16 Gómez-Blanco J, Luque D, González JM, Carrascosa JL , Alfonso C, Trus B, Havens WM, Ghabrial SA, Castón JR . Cryoelectron microscopy reconstruction of Cryphonectria nitschkei virus 1, a double-stranded RNA (dsRNA) virus, shows that...
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Genetic basis of adaptation in Arabidopsis thaliana: local adaptation at the seed dormancy QTL DOG1
Evolution 66, 2287–2302 Kronholm I, Picó FX, Alonso-Blanco C , Goudet J, Meaux JD. Local adaptation provides an opportunity to study the genetic basis of adaptation and investigate the allelic architecture of adaptive genes. We study DELAY OF...
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Label-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces
Nat Mater. 2012 Jul 8 Fumagalli L, Esteban-Ferrer D, Cuervo A, Carrascosa JL , Gomila G. Label-free detection of the material composition of nanoparticles could be enabled by the quantification of the nanoparticles’ inherent dielectric response to an...
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Cra regulates the cross-talk between the two branches of the phosphoenolpyruvate : phosphotransferase system of Pseudomonas putida
Environ Microbiol. 2012 Jun 19 Chavarría M, Fuhrer T, Sauer U, Pflüger-Grau K, de Lorenzo V . The gene that encodes the catabolite repressor/activator, Cra (FruR), of Pseudomonas putida is divergent from the fruBKA operon for the uptake of fructose via...
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Epigenetics of embryonic stem cells
Adv Exp Med Biol. 2012;741:231-53 Calvanese V, Fraga MF . Understanding the molecular mechanisms involved in the control of cell differentiation during embryonic development is currently one of the main objectives of developmental biology. This...
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Chemokine receptor oligomerization: A further step toward chemokine function
Immunol Lett. 2012 Jul 30;145(1-2):23-9 Muñoz LM, Holgado BL, Martínez-A C , Rodríguez-Frade JM, Mellado M . A broad array of biological responses including cell polarization, movement, immune and inflammatory responses, as well as prevention of HIV-1...
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Role of actin cytoskeleton in brassinosteroid signaling and in its integration with the auxin response in plants
Dev Cell. 2012 Jun 12;22(6):1275-85 Lanza M, Garcia-Ponce B, Castrillo G, Catarecha P, Sauer M, Rodriguez-Serrano M, Páez-García A, Sánchez-Bermejo E, Tc M, Leo Del Puerto Y, Sandalio LM, Paz-Ares J , Leyva A . In plants, developmental programs and...
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Whole-Genome Sequence of Stenotrophomonas maltophilia D457, a Clinical Isolate and a Model Strain
J Bacteriol. 2012 Jul;194(13):3563-4 Lira F, Hernández A, Belda E, Sánchez MB, Moya A, Silva FJ, Martinez JL . Stenotrophomonas maltophilia is an opportunistic pathogen with an environmental origin, and it is an increasingly relevant cause of...
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Differential epigenetic compatibility of qnr antibiotic resistance determinants with the chromosome of Escherichia coli
PLoS One. 2012;7(5):e35149 Sanchez MB, Martinez JL . Environmental bacteria harbor a plethora of genes that, upon their horizontal transfer to new hosts, may confer resistance to antibiotics, although the number of such determinants actually acquired...
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Vector replication and expression of HIV-1 antigens by the HIV/AIDS vaccine candidate MVA-B is not affected by HIV-1 protease inhibitors
Virus Res. 2012 May 30 García-Arriaza J, Arnáez P, Jiménez JL, Gómez CE, Muñoz-Fernández MA, Esteban M . MVA-B is an attenuated poxvirus vector expressing human immunodeficiency virus type 1 Env, Gag, Pol, and Nef antigens from clade B, and is...
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Two-step demodulation based on the Gram-Schmidt orthonormalization method
Opt Lett. 2012 Feb 1;37(3):443-5 Vargas J, Quiroga JA, Sorzano CO, Estrada JC, Carazo JM . This Letter presents an efficient, fast, and straightforward two-step demodulating method based on a Gram-Schmidt (GS) orthonormalization approach. The...
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Metagenomics and antibiotics
Clin Microbiol Infect. 2012 Jul;18 Suppl 4:27-31 Garmendia L, Hernandez A, Sanchez MB, Martinez JL . Most of the bacterial species that form part of the biosphere have never been cultivated. In this situation, a comprehensive study of bacterial...
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Broadening the signal specificity of prokaryotic promoters by modifying cis-regulatory elements associated with a single transcription factor
Mol Biosyst. 2012 Jul 6;8(7):1950-7 Silva-Rocha R, de Lorenzo V . In this report, we experimentally demonstrate that improving the cis -regulatory region of a target promoter can significantly enhance the response to an otherwise poor inducer. The...