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Defense activated by 9-lipoxygenase-derived oxylipins requires specific mitochondrial proteins
Plant Physiol. 2013 Feb;161(2):617-27 Vellosillo T, Aguilera V, Marcos R, Bartsch M, Vicente J, Cascón T, Hamberg M, Castresana C . 9-Lipoxygenases ( 9-LOXs ) initiate fatty acid oxygenation, resulting in the formation of oxylipins activating plant...
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Crystal ball – 2013
Microb Biotechnol. 2013 Jan;6(1):3-16 Curtis T, Daran JM, Pronk JT, Frey J, Jansson JK, Robbins-Pianka A, Knight R, Schnürer A, Smets BF, Smid EJ, Abee T, Vicente M , Zengler K. In this feature, leading researchers in the field of environmental...
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A Specific Role for the ZipA Protein in Cell Division: stabilization of the FtsZ protein
J Biol Chem. 2013 Feb 1;288(5):3219-26 Pazos M, Natale P, Vicente M . In Escherichia coli , the cell division protein FtsZ is anchored to the cytoplasmic membrane by the action of the bitopic membrane protein ZipA and the cytoplasmic protein FtsA....
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Stochasticity of TOL plasmid catabolic promoters sets a bimodal expression regime in Pseudomonas putida mt-2 exposed to m-xylene
Mol Microbiol. 2012 Oct;86(1):199-211 Silva-Rocha R, de Lorenzo V . The expression dynamics of the catabolic promoters of the TOL plasmid pWW0 has been examined in single cells of Pseudomonas putida mt-2 exposed to m- xylene. To this end, we employed...
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The flowering repressor SVP underlies a novel Arabidopsis thaliana QTL interacting with the genetic background
PLoS Genet 9(1): e1003289 Méndez-Vigo B, Martínez-Zapater JM, Alonso-Blanco C . The timing of flowering initiation is a fundamental trait for the adaptation of annual plants to different environments. Large amounts of intraspecific quantitative...
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A guide for integration of proteomic data standards into laboratory workflows
Proteomics. 2013 Feb;13(3-4):480-92 Medina-Aunon JA , Krishna R, Ghali F, Albar JP, Jones AJ. The development of the HUPO-Proteomics Standards Initiative standard data formats and Minimum Information About a Proteomics Experiment guidelines facilitate...
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Plasticity facilitates sustainable growth in the commons
J. R. Soc. Interface 6 April 2013 vol. 10 no. 81 Cavaliere M, Poyatos JF . In the commons, communities whose growth depends on public good, individuals often rely on surprisingly simple strategies, or heuristics, to decide whether to contribute to the...
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The role of the proto-oncogene c-myc in B lymphocyte differentiation
Crit Rev Immunol. 2012;32(4):321-34 Fernandez D, Sanchez-Arevalo VJ, de Alboran IM . Since the discovery of the myc gene, few genes are likely to have such influence on biomedical research. The diversity of the biological functions regulated by this...
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Genome expression analysis of nonproliferating intracellular Salmonella enterica serovar Typhimurium unravels an acid pH-dependent PhoP-PhoQ response essential for dormancy
Infect Immun. 2013 Jan;81(1):154-65 Núñez-Hernández C, Tierrez A, Ortega AD, Pucciarelli MG, Godoy M, Eisman B, Casadesús J, García-Del Portillo F . Genome-wide expression analyses have provided clues on how Salmonella proliferates inside cultured...
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Mechanical identities of RNA and DNA double helices unveiled at the single-molecule level
J Am Chem Soc. 2013 Jan 9;135(1):122-31 Herrero-Galán E, Fuentes-Perez ME, Carrasco C, Valpuesta JM , Carrascosa JL , Moreno-Herrero F , Arias-Gonzalez JR. Double-stranded (ds) RNA is the genetic material of a variety of viruses and has been recently...
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Protein chimerism: Novel source of protein diversity in humans adds complexity to bottom-up proteomics
Proteomics. 2013 Jan;13(1):5-11 Casado-Vela J , Lacal JC, Elortza F. Three main molecular mechanisms are considered to contribute expanding the repertoire and diversity of proteins present in living organisms: first, at DNA level (gene polymorphisms...
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Virus factories: biogenesis and structural design
Cell Microbiol. 2013 Jan;15(1):24-34 de Castro IF, Volonté L, Risco C . Replication and assembly of many viruses occur in specific intracellular compartments known as ‘virus factories’. Our knowledge of the biogenesis and architecture of these unique...
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Bambi and sp8 expression mark digit tips and their absence shows that chick wing digits 2 and 3 are truncated
PLoS One. 2012;7(12):e52781 Casanova JC, Badia-Careaga C, Uribe V, Sanz-Ezquerro JJ . An often overlooked aspect of digit development is the special nature of the terminal phalanx, a specialized structure with characteristics distinct from other...
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Spanish Human Proteome Project: Dissection of Chromosome 16
J Proteome Res. 2012 Dec 12 Segura V, Medina-Aunon JA, Guruceaga E, Gharbi SI, González-Tejedo C, Sánchez Del Pino MM, Canals F, Fuentes M, Casal JI, Martínez-Bartolomé S, Elortza F, Mato JM, Arizmendi JM, Abian J, Oliveira E, Gil C, Vivanco F, Blanco...
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Phosphoinositide 3-kinase beta controls replication factor C assembly and function
Nucleic Acids Res. 2012 Nov 21 Redondo-Muñoz J, Rodríguez MJ, Silió V, Pérez-García V, Valpuesta JM , Carrera AC . Genomic integrity is preserved by the action of protein complexes that control DNA homeostasis. These include the sliding clamps,...
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N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods
J Cell Biol. 2012 Oct 29;199(3):527-44 Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futó K, Timpson P, Nixon C, Ma Y, Anton IM , Visegrády B, Insall RH, Oien K, Blyth K, Norman JC, Machesky LM. Metastasizing tumor...
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Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly
Infect Immun. 2012 Dec;80(12):4071-7 Garber JJ, Takeshima F, Anton IM , Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB. The human pathogens enteropathogenic Escherichia coli (EPEC) and vaccinia virus trigger...
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Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens
PLoS One. 2012;7(10):e48524 Perdiguero B, Gómez CE, Nájera JL, Sorzano CO, Delaloye J, González-Sanz R, Jiménez V, Roger T, Calandra T, Pantaleo G, Esteban M . Vaccinia virus (VACV) encodes an anti-apoptotic Bcl-2-like protein F1 that acts as an...
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A novel two-component system involved in secretion stress response in Streptomyces lividans
PLoS One. 2012;7(11):e48987 Gullón S, Vicente RL, Mellado RP . Misfolded proteins accumulating outside the bacterial cytoplasmic membrane can interfere with the secretory machinery, hence the existence of quality factors to eliminate these misfolded...
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Natural Arabidopsis brx loss-of-function alleles confer root adaptation to acidic soil
Curr Biol. 2012 Oct 23;22(20):1962-8 Gujas B, Alonso-Blanco C , Hardtke CS. Soil acidification is a major agricultural problem that negatively affects crop yield [ [1] and [2] ]. Root systems counteract detrimental passive proton influx from acidic...