Publicaciones Científicas Destacadas

Endogenous stress caused by faulty oxidation reactions fosters evolution of 2,4-dinitrotoluene-degrading bacteria

PLoS Genet. 2013 Aug;9(8):e1003764 Pérez-Pantoja D, Nikel PI, Chavarría M, de Lorenzo V . Environmental strain Burkholderia sp. DNT mineralizes the xenobiotic compound 2,4-dinitrotoluene (DNT) owing to the catabolic dnt genes borne by plasmid DNT, but...
DNA methylation-mediated silencing of PU.1 in leukemia cells resistant to cell differentiation

Springerplus. 2013 Aug 21;2:392 Fernández-Nestosa MJ, Monturus E, Sánchez Z, Torres FS, Fernández AF, Fraga MF , Hernández P, Schvartzman JB, Krimer DB. In mice, the proviral integration of the Friend Spleen Focus Forming Virus (SFFV) within the PU.1...
Structural characterization of the bacteriophage T7 tail machinery

J Biol Chem. 2013 Jul 24 Cuervo A, Pulido-Cid M, Chagoyen M , Arranz R, González-García VA, Garcia-Doval C, Castón JR , Valpuesta JM , van Raaij MJ , Martín-Benito J, Carrascosa JL . Most bacterial viruses need a specialized machinery, called “tail,”...
Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications

J Control Release. 2013 Jul 29;171(2):225-233 Mejías R, Gutiérrez L, Salas G, Pérez-Yagüe S, Zotes TM, Lázaro FJ, Morales MP, Barber DF . Although iron oxide magnetic nanoparticles (MNP) have been proposed for numerous biomedical applications, little...
TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases

J Immunol. 2013 Oct 1;191(7):3867-75 Barrio L, Saez de Guinoa J, Carrasco YR . B cells use a plethora of TLR to recognize pathogen-derived ligands. These innate signals have an important function in the B cell adaptive immune response and modify their...
PI3K p110δ is expressed by gp38−CD31+ and gp38+CD31+ spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels

PLoS One. 2013 Aug 22;8(8):e72960 Zotes TM, Spada R, Mulens V, Pérez-Yagüe S, Sorzano CO, Okkenhaug K, Carrera AC , Barber DF . The role of p110δ PI3K in lymphoid cells has been studied extensively, showing its importance in immune cell...
PI3K p110γ deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions

PLoS One. 2013 Aug 22;8(8):e72674 Zotes TM, Arias CF, Fuster JJ, Spada R, Pérez-Yagüe S, Hirsch E, Wymann M, Carrera AC , Andrés V, Barber DF . Atherosclerosis is an inflammatory disease regulated by infiltrating monocytes and T cells, among other cell...
DNA methylation signatures identify biologically distinct thyroid cancer subtypes

J Clin Endocrinol Metab. 2013 Jul;98(7):2811-21 Rodríguez-Rodero S, Fernández AF, Fernández-Morera JL, Castro-Santos P, Bayon GF, Ferrero C, Urdinguio RG, Gonzalez-Marquez R, Suarez C, Fernández-Vega I, Fresno Forcelledo MF, Martínez-Camblor P,...
A DNA methylation signature associated with the epigenetic repression of glycine N-methyltransferase in human hepatocellular carcinoma

J Mol Med. 2013 Aug;91(8):939-50 Huidobro C, Toraño EG, Fernández AF, Urdinguio RG, Rodríguez RM, Ferrero C, Martínez-Camblor P, Boix L, Bruix J, García-Rodríguez JL, Varela-Rey M, Mato JM, Martínez-Chantar ML, Fraga MF . The basic mechanisms...
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention

Cancer Cell. 2013 Jul 8;24(1):15-29 Rad R, Cadiñanos J, Rad L, Varela I, Strong A, Kriegl L, Constantino-Casas F, Eser S, Hieber M, Seidler B, Price S, Fraga MF , Calvanese V, Hoffman G, Ponstingl H, Schneider G, Yusa K, Grove C, Schmid RM, Wang W,...
Genetic and non-genetic predictors of LINE-1 methylation in leukocyte DNA

Environ Health Perspect. 2013 Jun;121(6):650-6 Tajuddin SM, Amaral AF, Fernández AF, Rodríguez-Rodero S, Rodríguez RM, Moore LE, Tardón A, Carrato A, García-Closas M, Silverman DT, Jackson BP, García-Closas R, Cook AL, Cantor KP, Chanock S, Kogevinas...
The Escherichia coli divisome: born to divide

Environ Microbiol. 2013 Aug 1 Natale P, Pazos M, Vicente M . Septation in Escherichia coli involves complex molecular mechanisms that contribute to the accuracy of bacterial division. The proto-ring, a complex made up by the FtsZ, FtsA and ZipA...
O-GlcNAc modification of the coat protein of the potyvirus Plum pox virus enhances viral infection

Virology. 2013 Aug 1;442(2):122-31 Pérez Jde J, Udeshi ND, Shabanowitz J, Ciordia S, Juárez S, Scott CL, Olszewski NE, Hunt DF, García JA . O -GlcNAcylation is a dynamic protein modification which has been studied mainly in metazoans. We reported...
Metabolic and regulatory rearrangements underlying glycerol metabolism in Pseudomonas putida KT2440

Environ Microbiol. 2013 Jul 25. doi: 10.1111/1462-2920.12224 Nikel PI, Kim J, de Lorenzo V . While the natural niches of the soil bacterium Pseudomonas putida are unlikely to include significant amounts of free glycerol as a growth substrate, this...
Mycobacterium tuberculosis shikimate kinase inhibitors: design and simulation studies of the catalytic turnover

J Am Chem Soc. 2013 Aug 21;135(33):12366-76 Blanco B, Prado V, Lence E, Otero JM, Garcia-Doval C, van Raaij MJ , Llamas-Saiz AL, Lamb H, Hawkins AR, González-Bello C. Shikimate kinase (SK) is an essential enzyme in several pathogenic bacteria and does...
WIP regulates persistence of cell migration and ruffle formation in both mesenchymal and amoeboid modes of motility

PLoS One. 2013 Aug 7;8(8):e70364 Banon-Rodriguez I, Saez de Guinoa J, Bernardini A, Ragazzini C, Fernandez E, Carrasco YR, Jones GE, Wandosell F, Anton IM . The spatial distribution of signals downstream from receptor tyrosine kinases (RTKs) or...
Interactions among the early Escherichia coli divisome proteins revealed by bimolecular fluorescence complementation

Environ Microbiol. 2013 Aug 1. doi: 10.1111/1462-2920.12225 Pazos M, Natale P, Margolin W, Vicente M . We used bimolecular fluorescence complementation (BiFC) assays to detect protein-protein interactions of all possible pairs of the essential...
Large terminase conformational change induced by connector binding in bacteriophage T7

J Biol Chem. 2013 Jun 7;288(23):16998-7007 Daudén MI, Martín-Benito J, Sánchez-Ferrero JC, Pulido-Cid M, Valpuesta JM , Carrascosa JL . During bacteriophage morphogenesis DNA is translocated into a preformed prohead by the complex formed by the portal...
Particle quality assessment and sorting for automatic and semiautomatic particle-picking techniques

J Struct Biol. 2013 Aug 6. pii: S1047-8477(13)00195-0 Vargas J, Abrishami V, Marabini R, de la Rosa-Trevín JM, Zaldivar A, Carazo JM , Sorzano CO. Three-dimensional reconstruction of biological specimens using electron microscopy by single particle...
Protein arrays: recent achievements and their application to study the human proteome

Curr Proteomics. 2013; 10(2):83-97 Casado-Vela J , González-González M, Matarraz S, Martínez-Esteso MJ, Vilella M, Sayagues JM, FuentesM, Lacal JC. Protein arrays represent a step forward in proteomic technologies, as they enable to address biological...

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