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Monitoring dynamics of human adenovirus disassembly induced by mechanical fatigue
Sci Rep. 2013;3:1434 Ortega-Esteban A, Pérez-Berná AJ, Menéndez-Conejero R, Flint SJ, San Martín C , de Pablo PJ. The standard pathway for virus infection of eukaryotic cells requires disassembly of the viral shell to facilitate release of the viral...
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The animal food supplement sepiolite promotes a direct horizontal transfer of antibiotic resistance plasmids between bacterial species
Antimicrob Agents Chemother. 2013 Jun;57(6):2651-3 Rodríguez-Beltrán J, Rodríguez-Rojas A, Yubero E, Blázquez J . Animal fodder is routinely complemented with antibiotics together with other food supplements to improve growth. For instance, sepiolite...
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Protein-protein interactions: gene acronym redundancies and current limitations precluding automated data integration
Proteomes 2013, 1(1), 3-24 Casado-Vela J, Matthiesen R, Sellés S, Naranjo JR . Understanding protein interaction networks and their dynamic changes is a major challenge in modern biology. Currently, several experimental and in silico approaches allow...
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The proto-oncogene c-myc regulates antibody secretion and Ig class switch recombination
J Immunol. 2013 Jun 15;190(12):6135-44 Fernández D, Ortiz M, Rodríguez L, García A, Martinez D, Moreno de Alborán I . The immune response involves the generation of Ab-secreting cells and memory B cells through a process called terminal B lymphocyte...
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CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection
J Virol. 2013 Apr;87(8):4534-44 Alfonso R, Rodriguez A, Rodriguez P, Lutz T, Nieto A . The influenza virus polymerase associates to an important number of transcription-related proteins, including the largest subunit of the RNA polymerase II complex...
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Gadd45g is essential for primary sex determination, male fertility and testis development
PLoS ONE 8(3): e58751 Johnen H, González-Silva L, Carramolino L, Flores JM, Torres M, Salvador JM . In humans and most mammals, differentiation of the embryonic gonad into ovaries or testes is controlled by the Y-linked gene SRY . Here we show a role...
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BRANCHED1 promotes axillary bud dormancy in response to shade in Arabidopsis
Plant Cell. 2013; 25(3): 834-850 González-Grandío E, Poza-Carrión C, Sorzano CO, Cubas P . Plants interpret a decrease in the red to far-red light ratio (R:FR) as a sign of impending shading by neighboring vegetation. This triggers a set of...
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Structural insights into the chaperone activity of the 40 kDa heat shock protein DnaJ. Binding and remodeling of a native substrate
J Biol Chem. 2013 Apr 11 Cuellar J, Perales-Calvo J, Muga A, Valpuesta JM , Moro F. Hsp40 chaperones bind and transfer substrate proteins to Hsp70s and regulate their ATPase activity. The interaction of Hsp40s with native proteins modifies their...
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Bacteriophage SPP1 DNA replication strategies promote viral and disable host replication in vitro
Nucleic Acids Res. 2013 Feb 1;41(3):1711-21 Seco EM, Zinder JC, Manhart CM, Lo Piano A, McHenry CS, Ayora S . Complex viruses that encode their own initiation proteins and subvert the host's elongation apparatus have provided valuable insights into DNA...
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Attenuated and replication competent Vaccinia Virus strains M65 and M101 with distinct biology and immunogenicity as potential vaccine candidates against pathogens
J Virol. 2013 Apr 17 Sánchez-Sampedro L, Gómez CE, Mejías-Pérez E, Pérez-Jiménez E, Oliveros JC, Esteban M . Replication competent poxvirus vectors with an attenuation phenotype and with high immunogenic capacity of the foreign expressed antigen are...
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High, broad, polyfunctional and durable T cell immune responses induced in mice by a novel hepatitis C virus (HCV) vaccine candidate based on MVA expressing the near full-length HCV genome (MVA-HCV)
J Virol. 2013 Jul;87(13):7282-300 Gómez CE, Perdiguero B, Cepeda MV, Mingorance L, García-Arriaza J, Vandermeeren A, Sorzano CO, Esteban M . A major goal in the control of hepatitis C infection is the development of a vaccine. Here, we have developed a...
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Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation
PNAS April 8, 2013 Li B, Wang Q, Pan X, Fernández de Castro I, Sun Y, Guo Y, Tao X, Risco C , Su SF, Lou Z. Bunyamwera virus (BUNV), which belongs to the genus Orthobunyavirus , is the prototypical virus of the Bunyaviridae family. Similar to other...
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Chrysovirus structure: repeated helical core as evidence of gene duplication
Adv Virus Res. 2013;86:87-108 Castón JR , Luque D, Gómez-Blanco J, Ghabrial SA. Chrysoviruses are double-stranded RNA viruses with a multipartite genome. Structure of two fungal chrysoviruses, Penicillium chrysogenum virus and Cryphonectria nitschkei...
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High-throughput proteomic characterization of plasma rich in growth factors (PRGF-Endoret)-derived fibrin clot interactome
J Tissue Eng Regen Med. 2013; doi: 10.1002/term.1721. Anitua E1, Prado R, Azkargorta M, Rodriguez-Suárez E, Iloro I, Casado-Vela J , Elortza F, Orive G. Plasma rich in growth factors (PRGF®-Endoret®) is an autologous technology that contains a set of...
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Why are chlorinated pollutants so difficult to degrade aerobically? Redox stress limits 1,3-dichloprop-1-ene metabolism by Pseudomonas pavonaceae
Philos Trans R Soc Lond B Biol Sci. 2013 Mar 11;368(1616):20120377 Nikel PI, Pérez-Pantoja D, de Lorenzo V . Chlorinated pollutants are hardly biodegradable under oxic conditions, but they can often be metabolized by anaerobic bacteria through...
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Rotavirus viroplasm proteins interact with the cellular SUMOylation system: implications for viroplasm-like structure formation
J Virol. 2013 Jan;87(2):807-17 Campagna M, Marcos-Villar L, Arnoldi F, de la Cruz-Herrera CF, Gallego P, González-Santamaría J, González D, Lopitz-Otsoa F, Rodriguez MS, Burrone OR, Rivas C . Posttranslational modification by SUMO provides functional...
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Among- and within-population variation in flowering time of Iberian Arabidopsis thaliana estimated in field and glasshouse conditions
New Phytol. 2013 Mar;197(4):1332-43 Méndez-Vigo B, Gomaa NH, Alonso-Blanco C , Xavier Picó F. The study of the evolutionary and population genetics of quantitative traits requires the assessment of within- and among-population patterns of variation. We...
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Analysis of metagenomic data containing high biodiversity levels
PLoS ONE 8(3): e58118 Valverde JR , Mellado RP . In this paper we have addressed the problem of analysing Next Generation Sequencing samples with an expected large biodiversity content. We analysed several well-known 16S rRNA datasets from experimental...
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Real-time detection of the chemokine CXCL12 in urine samples by surface plasmon resonance
Talanta. doi: 10.1016/j.talanta.2013.02.018 Vega B, Calle A, Sánchez A, Lechuga LM, Ortiz AM, Armelles G, Rodríguez-Frade JM, Mellado M . Surface plasmon resonance (SPR)-based biosensors are established tools for measuring biomolecular interactions...
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Effect of anesthesia on magnetic nanoparticle biodistribution after intravenous injection
IEEE Trans Magn. 2013 Jan;49(1):398-401 Mejias R, Lazaro FJ, Serna CJ, Barber DF , Morales MP. The role of anesthesia on magnetic nanoparticle biodistribution among different organs after intravenous injection has been studied in a murine model....