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Functional significance of SRJ domain mutations in CITED2
PLoS One. 2012;7(10):e46256 Chen CM, Bentham J, Cosgrove C, Braganca J, Cuenda A , Bamforth SD, Schneider JE, Watkins H, Keavney B, Davies B, Bhattacharya S. GCITED2 is a transcriptional co-activator with 3 conserved domains shared with other CITED...
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The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
Nat Immunol. 2012 Nov;13(11):1092-100 Calado DP, Sasaki Y, Godinho SA, Pellerin A, Köchert K, Sleckman BP, de Alborán IM , Janz M, Rodig S, Rajewsky K. Germinal centers (GCs) are sites of intense B cell proliferation and are central for T...
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Increasing Signal Specificity of the TOL Network of Pseudomonas putida mt-2 by Rewiring the Connectivity of the Master Regulator XylR
PLoS Genet. 2012 Oct;8(10):e1002963 de Las Heras A, Fraile S, de Lorenzo V . Prokaryotic transcription factors (TFs) that bind small xenobiotic molecules (e.g., TFs that drive genes that respond to environmental pollutants) often display a promiscuous...
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Structural and functional concepts in current mouse phenotyping and archiving facilities
J Am Assoc Lab Anim Sci. 2012;51(4):418-35 Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L , Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, de Angelis MH, Schughart K. Collecting and analyzing available...
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High-resolution structures of Thermus thermophilus enoyl-acyl carrier protein reductase in the apo form, in complex with NAD(+) and in complex with NAD(+) and triclosan
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1139-48 Otero JM, Noël AJ, Guardado-Calvo P, Llamas-Saiz AL, Wende W, Schierling B, Pingoud A, van Raaij MJ . Enoyl-acyl carrier protein reductase (ENR; the product of the fab I...
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‘Inverted’ analogs of the antibiotic gramicidin S with an improved biological profile
Bioorg Med Chem. 2012 Oct 15;20(20):6059-62 Kapoerchan VV, Knijnenburg AD, Keizer P, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ , van der Marel GA, Overkleeft HS, Overhand M. A series of gramicidin S...
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Genetic recombination in Bacillus subtilis: a division of labor between two single-strand DNA-binding proteins
Nucleic Acids Res. 2012 Jul;40(12):5546-59 Yadav T, Carrasco B, Myers AR, George NP, Keck JL, Alonso JC . We have investigated the structural, biochemical and cellular roles of the two single-stranded (ss) DNA-binding proteins from Bacillus subtilis ,...
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Immunoglobulin domains in Escherichia coli and other enterobacteria: from pathogenesis to applications in antibody technologies
FEMS Microbiol Rev. 2012 Jun 22 Bodelón G, Palomino C, Fernández LA . The immunoglobulin (Ig) protein domain is widespread in nature having a well-recognized role in proteins of the immune system. In this review, we describe the proteins containing...
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The VP3 factor from viruses of Birnaviridae family suppresses RNA silencing by binding both long and small RNA duplexes
PLoS ONE 7(9): e45957 Valli A, Busnadiego I, Maliogka V, Ferrero D, Castón JR , Rodríguez JF , García JA . RNA silencing is directly involved in antiviral defense in a wide variety of eukaryotic organisms, including plants, fungi, invertebrates, and...
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Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells
Cell Mol Life Sci. 2012 Sep 23 Parrillas V, Martínez-Muñoz L, Holgado BL, Kumar A, Cascio G, Lucas P, Rodríguez-Frade JM, Malumbres M, Carrera AC, van Wely KH, Mellado M . Hypermethylation of SOCS genes is associated with many human cancers, suggesting...
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Efficient orthogonal integration of the bacteriophage phi29 DNA-portal connector protein in engineered lipid bilayers
ACS Synth. Biol., 2012, 1 (9), pp 414–424 Moleiro LH, López-Montero I, Márquez I, Moreno S, Vélez M, Carrascosa JL , Monroy F. The portal connector of bacteriophage viruses constitutes a robust molecular machine for DNA translocation. In this paper we...
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Metaproteogenomic insights beyond bacterial response to naphthalene exposure and bio-stimulation
ISME J. 2012 Jul 26 Guazzaroni ME, Herbst FA, Lores I, Tamames J , Peláez AI, López-Cortés N, Alcaide M, Del Pozo MV, Vieites JM, von Bergen M, Gallego JL, Bargiela R, López-López A, Pieper DH, Rosselló-Móra R, Sánchez J, Seifert J, Ferrer M. Microbial...
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On the fitness of microbial taxonomy
Trends Microbiol. 2012 Sep 4 Tamames J , Rosselló-Móra R. Microbial taxonomy seems to be an expanding discipline especially in Asian countries. By contrast, the number of taxonomists in Western countries are in decline, and the reasons for this could...
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Microstructural, textural and colour characteristics during ripening of hispánico cheese made using high-pressure-treated ovine milk curd
Food Bioprocess Tech. 2012, doi: 10.1007/s11947-012-0955-x A. Picon, R. Alonso, K. H. M. van Wely , M. Nuñez. High-pressure (HP) treatment of curd at low temperatures, on top of efficiently reducing microbial loads while maintaining most of the...
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Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies
PLoS Pathog. 2012 Aug;8(8):e1002859 Reguera J, Santiago C, Mudgal G, Ordoño D, Enjuanes L , Casasnovas JM . The coronaviruses (CoVs) are enveloped viruses of animals and humans associated mostly with enteric and respiratory diseases, such as the severe...
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Diacylglycerol kinase ζ: at the crossroads of lipid signaling and protein complex organization
Prog Lipid Res. 2012 Jan;51(1):1-10 Rincón E, Gharbi SI, Santos-Mendoza T, Mérida I . Diacylglycerol (DAG) and phosphatidic acid (PA) are lipids with unique functions as metabolic intermediates, basic membrane constituents, and second-signal...
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Entropy involved in fidelity of DNA replication
PLoS ONE 7(8): e42272 Arias-Gonzalez JR . Information has an entropic character which can be analyzed within the framework of the Statistical Theory in molecular systems. R. Landauer and C.H. Bennett showed that a logical copy can be carried out in the...
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Heterologous RNA-silencing suppressors from both plant- and animal-infecting viruses support plum pox virus infection
J Gen Virol. 2012 Jul;93(Pt 7):1601-11 Maliogka VI, Calvo M, Carbonell A, García JA , Valli A. HCPro, the RNA-silencing suppressor (RSS) of viruses belonging to the genus Potyvirus in the family Potyviridae , is a multifunctional protein presumably...
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Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: MurA confers clinical resistance at low fitness cost
Antimicrob Agents Chemother. 2012 May;56(5):2767-9 Couce A, Briales A, Rodríguez-Rojas A, Costas C, Pascual A, Blázquez J . To determine whether the overexpression of chromosomal genes can confer fosfomycin resistance, genomewide screening of a...
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EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5
FASEB J. 2012 Aug 23 Barroso R, Martínez Muñoz L, Barrondo S, Vega B, Holgado BL, Lucas P, Baíllo A, Sallés J, Rodríguez-Frade JM , Mellado M . B-cell movement into lymphoid follicles depends on the expression of the chemokine receptor CXCR5 and the...