-
Hormone-mediated disassembly and inactivation of a plant E3 ubiquitin ligase complex
Cell Rep. 2024 Oct 3;43(10):114802. Martínez C, Iniesto E, García-León M, García-Corredera D, Fonseca S, Santiago C, Yang M, Yu R, Chen H, Altmann E, Renatus M, Deng XW, Rubio V. Abstract Phytohormone abscisic acid (ABA) regulates key plant development...
-
Reconceptualizing transcriptional slippage in plant RNA viruses
mBio . 2024 Sep 17:e0212024. Valli AA, Domingo-Calap ML, González de Prádena A, García JA, Cui H, Desbiez C, López-Moya JJ. Abstract RNA viruses have evolved sophisticated strategies to exploit the limited encoded information within their typically...
-
Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain
Elife 2024 Sep 9:13:RP93968. García-Cuesta EM, Martínez P, Selvaraju K, Ulltjärn G, Gómez Pozo AM, D’Agostino G, Gardeta S, Quijada-Freire A, Blanco Gabella P, Roca C, Hoyo DD, Jiménez-Saiz R, García-Rubia A, Soler Palacios B, Lucas P, Ayala-Bueno R,...
-
MVA-based vaccine candidates expressing SARS-CoV-2 prefusion-stabilized spike proteins of the Wuhan, Beta or Omicron BA.1 variants protect transgenic K18-hACE2 mice against Omicron infection and elicit robust and broad specific humoral and cellular i
Front Immunol. 2024 Aug 29:15:1420304. Pérez P, Astorgano D, Albericio G, Flores S, Sánchez-Corzo C, Noriega MA, Sánchez-Cordón PJ, Labiod N, Delgado R, Casasnovas JM, Esteban M, García-Arriaza J.. Abstract Despite the decrease in mortality and...
-
GLABRA2 transcription factor integrates arsenic tolerance with epidermal cell fate determination
New Phytol. 2024 Sep 5. Navarro MA, Navarro C, Hernández LE, Garnica M, Franco-Zorrilla JM, Burko Y, González-Serrano S, García-Mina JM, Pruneda-Paz J, Chory J, Leyva A. Abstract Arsenic poses a global threat to living organisms, compromising crop...
-
Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria
Nat Ecol Evol. 2024 Aug 28. Sastre-Dominguez J, DelaFuente J, Toribio-Celestino L, Herencias C, Herrador-Gómez P, Costas C, Hernández-García M, Cantón R, Rodríguez-Beltrán J, Santos-Lopez A*, San Millan A* * Contributed equally. Abstract Plasmids are...
-
Novel Mechanisms of Strigolactone-Induced DWARF14 Degradation in Arabidopsis thaliana
J Exp Bot. 2024 Aug 28:erae365. Martín-Fontecha ES, Cardinale F, Bürger M, Prandi C, Cubas P Abstract In angiosperms, the strigolactone (SL) receptor is the α/β hydrolase DWARF14 (D14) that, upon SL binding, undergoes conformational changes, triggers...
-
Cross-biome microbial networks reveal functional redundancy and suggest genome reduction through functional complementarity
Commun Biol. 2024 Aug 24 ; 7(1):1046. Puente-Sánchez F, Pascual-García A, Bastolla U, Pedrós-Alió C, Tamames J. Abstract The structure of microbial communities arises from a multitude of factors, including the interactions of microorganisms with each...
-
WatFinder: A ProDy tool for protein-water interactions
Bioinformatics. 2024 Aug 17:btae516 Krieger JM, Doljanin F, Bogetti AT, Zhang F, Manivarma T, Bahar I, Mikulska-Ruminska K. Abstract Summary: We introduce WatFinder, a tool designed to identify and visualize protein-water interactions (water bridges,...
-
A potential therapeutic strategy based on acute oxidative stress induction for wild-type NRF2/KEAP1 lung squamous cell carcinoma
Redox Biol. 2024 Sep ;75:103305. Epub 2024 Aug 8. Sánchez-Ortega M, Garrido A, Cirauqui C, Sanz-Gonzalez L, Hernández MC, González-García A, Obregon K, Ferrer I, Paz-Ares L, Carrera AC. Abstract Extensive efforts have been conducted in the search for...
-
Heterologous mRNA/MVA delivering trimeric-RBD as effective vaccination regimen against SARS-CoV-2: COVARNA Consortium
Emerg Microbes Infect. 2024 Dec;13(1):2387906. Epub 2024 Aug 8. Marcos-Villar L, Perdiguero B, López-Bravo M, Zamora C, Sin L, Álvarez E, Sorzano CÓS, Sánchez-Cordón PJ, Casasnovas JM, Astorgano D, García-Arriaza J, Anthiya S, Borrajo ML, Lou G, Cuesta...
-
Conformational Dynamics of Influenza A Virus Ribonucleoprotein Complexes during RNA Synthesis
ACS Nano. 2024 Jul 16 Carlero D, Fukuda S, Bocanegra R, Ando T, Martin-Benito J, Ibarra B Abstract Viral ribonucleoproteins (vRNPs) are the cornerstones of viral proliferation, as they form the macromolecular complexes that are responsible for the...
-
Hepatitis C virus-induced differential transcriptional traits in host cells after persistent infection elimination by direct-acting antivirals in cell culture
J Med Virol . 2024 Jul;96(7):e29787 Castro V, Calvo G, Oliveros JC, Pérez-Del-Pulgar S, Gastaminza P Abstract Chronic hepatitis C virus infection (HCV) causes liver inflammation and fibrosis, leading to the development of severe liver disease, such as...
-
Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains
Nat Commun . 2024 Jul 3;15(1):5583 Ukleja M, Kricks L, Torrens G, Peschiera I, Rodrigues-Lopes I, Krupka M, García-Fernández J, Melero R, Del Campo R, Eulalio A, Mateus A, López-Bravo M, Rico AI, Cava F, Lopez D. Abstract The function of many bacterial...
-
Inactivation of Pseudomonas putida KT2440 pyruvate dehydrogenase relieves catabolite repression and improves the usefulness of this strain for degrading aromatic compounds
Microb Biotechnol. 2024 Jun;17(6):e14514 Moreno R, Yuste L, Morales G, Rojo F Abstract Pyruvate dehydrogenase (PDH) catalyses the irreversible decarboxylation of pyruvate to acetyl-CoA, which feeds the tricarboxylic acid cycle. We investigated how the...
-
Targeting the protein folding transition state by mutation: Large scale (un)folding rate accelerations without altering native stability
Protein Sci. 2024 Jul;33(7):e5031 Campos LA, Muñoz V. Abstract Proteins are constantly undergoing folding and unfolding transitions, with rates that determine their homeostasis in vivo and modulate their biological function. The ability to optimize...
-
BCG priming followed by a novel interleukin combination activates Natural Killer cells to selectively proliferate and become anti-tumour long-lived effectors
Sci Rep . 2024 Jun 7;14(1):13133 Felgueres MJ, Esteso G, García-Jiménez ÁF, Dopazo A, Aguiló N, Mestre-Durán C, Martínez-Piñeiro L, Pérez-Martínez A, Reyburn HT, Valés-Gómez M Abstract The short-lived nature and heterogeneity of Natural Killer (NK)...
-
Functional antibody responses targeting the Spike protein of SARS-CoV-2 Omicron XBB.1.5 in elderly nursing home residents following Wuhan-Hu-1-based mRNA booster vaccination
Sci Rep . 2024 May 24;14(1):11896 Sánchez-Simarro Á*, Fernández-Soto D*, Grau B, Albert E*, Giménez E, Avilés-Alía AI, Gozalbo-Rovira R, Rusu L, Olea B, Geller R, Reyburn HT, Navarro D * Contributed equally. Abstract The immune effector mechanisms...
-
Global epistasis and the emergence of function in microbial consortia
Cell 187, 1–12. June 6, 2024. Diaz-Colunga J, Skwara A, Vila JCC, Bajic D, Sanchez A Abstract The many functions of microbial communities emerge from a complex web of interactions between organisms and their environment. This poses a significant...
-
GLR-dependent calcium and electrical signals are not coupled to systemic, oxylipin-based wound-induced gene expression in Marchantia polymorpha
New Phytol. 2024 May 10. doi: 10.1111/nph.19803 Sanmartín M, Rojo E, Kurenda A, Larruy-García B, Zamarreño ÁM, Delgadillo MO, Brito-Gutiérrez P, García-Mina JM, Farmer EE, Sánchez-Serrano JJ Abstract In angiosperms, wound-derived signals travel through...