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Interaction of Iron Oxide Nanoparticles with Macrophages Is Influenced Distinctly by "Self" and "Non-Self" Biological Identities
ACS Appl Mater Interfaces. 2023 Aug 2;15(30):35906-35926. Yadileiny Portilla, Vladimir Mulens-Arias, Neus Daviu, Alberto Paradela, Sonia Pérez-Yagüe, Domingo F Barber Abstract Upon contact with biological fluids like serum, a protein corona (PC)...
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p38γ and p38δ modulate innate immune response by regulating MEF2D activation
Elife. 2023 Jul 17;12:e86200. Alejandra Escós, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego González-Romero, Ana Risco, José Martín-Gómez, Éric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan José Sanz-Ezquerro, Steven C Ley, Ana...
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Fitness-Dependent, Mild Mutagenic Activity of Sofosbuvir for Hepatitis C Virus
Antimicrob Agents Chemother . 2023 Jul 18;67(7):e0039423. Brenda Martínez-González , Isabel Gallego, Josep Gregori, María Eugenia Soria, Pilar Somovilla, Ana Isabel de Ávila, Carlos García-Crespo, Antoni Durán-Pastor, Carlos Briones, Jordi Gómez, Josep...
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Synthetic Biology─High Time to Deliver?
ACS Synth Biol. 2023 Jun 16;12(6):1579-1582 . AD Hanson, V de Lorenzo Abstract Synthetic biology (SynBio) has attracted like no other recent development the attention not only of Life Science researchers and engineers but also of intellectuals,...
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MBROLE3: improved functional enrichment of chemical compounds for metabolomics data analysis
Nucleic Acids Res. 2023 May 13;gkad405. J Lopez-Ibañez, F Pazos, M Chagoyen Abstract MBROLE (Metabolites Biological Role) facilitates the biological interpretation of metabolomics experiments. It performs enrichment analysis of a set of chemical...
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In Vivo Sampling of Intracellular Heterogeneity of Pseudomonas putida Enables Multiobjective Optimization of Genetic Devices
ACS Synth Biol. 2023 Jun 16;12(6):1667-1676. Epub 2023 May 17. A Hueso-Gil, BCalles, V de Lorenzo Abstract The inner physicochemical heterogeneity of bacterial cells generates three-dimensional (3D)-dependent variations of resources for effective...
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Tackling antibiotic resistance by inducing transient and robust collateral sensitivity
Nat Commun. 2023 Mar 30;14(1):1723. Sara Hernando-Amado, Pablo Laborda, José Luis Martínez Abstract Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational acquisition of antibiotic resistance (AR). However, AR...
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Evolution of the jasmonate ligands and their biosynthetic pathways
New Phytol. 2023 Mar 21. Andrea Chini, Isabel Monte, Angel M Zamarreño, José M García-Mina, Roberto Solano Abstract Different plant species employ different jasmonates to activate a conserved signalling pathway in land plants, where (+)-7-iso-JA-Ile...
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Rapid Phenotypic Convergence towards Collateral Sensitivity in Clinical Isolates of Pseudomonas aeruginosa Presenting Different Genomic Backgrounds
Microbiol Spectr. 2023 Feb 14;11(1):e0227622. Epub 2022 Dec 19. Hernando-Amado S, López-CausapéC, Laborda P, Sanz-García F, Oliver A, Martínez JL Abstract Collateral sensitivity (CS) is an evolutionary trade-off by which acquisition of resistance to an...
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Evolutionary diversification of methanotrophic ANME-1 archaea and their expansive virome
Nat Microbiol. 2023 Feb;8(2):231-245. Epub 2023 Jan 19. Laso-Pérez R, Wu F, Crémière A, Speth DR, Magyar JS ,Zhao K, Krupovic M, Orphan VJ Abstract 'Candidatus Methanophagales' (ANME-1) is an order-level clade of archaea responsible for anaerobic...
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APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining
Cell Rep. 2023 Jan 31;42(1):111917. Epub 2022 Dec 31. De Bragança S, Aicart-Ramos C, Arribas-Bosacoma R, Rivera-Calzada A,Unfried AP, Prats-Mari L, Marin-Baquero M, Fortes P , Llorca O, Moreno-Herrero F Abstract The synapsis of DNA ends is a critical...
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Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials
Nat Commun. 2023 Jan 11;14(1):154. Herreros D, Lederman RR, Krieger JM, Jiménez-Moreno A, Martínez M, Myška D,Strelak D , Filipovic J, Sorzano COS, Carazo JM Abstract The new developments in Cryo-EM Single Particle Analysis are helping us to understand...
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SARS-CoV-2-Mediated Lung Edema and Replication Are Diminished by Cystic Fibrosis Transmembrane Conductance Regulator Modulators
mBio. 2023 Feb 28;14(1):e0313622. . Epub 2023 Jan 10. Honrubia JM, Gutierrez-Álvarez J, Sanz-Bravo A, González-Miranda E, Muñoz-Santos D, Castaño-Rodriguez C, Wang L, Villarejo-Torres M, Ripoll-Gómez J, Esteban A, Fernandez-Delgado R , Sánchez-Cordón...
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Rearranged Endogenized Plant Pararetroviruses as Evidence of Heritable RNA-based Immunity
Mol Biol Evol. 2023, 40(1):msac240. Valli AA , Gonzalo-Magro I,Sanchez DH Abstract Eukaryotic genomics frequently revealed historical spontaneous endogenization events of external invading nucleic acids, such as viral elements. In plants, an extensive...
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Evolution of CRISPR-associated Endonucleases as Inferred from Resurrected Proteins
Nature Microbiology 2023, 8(1):77-90 Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matías Morin, Almudena Fernández, Logan T. Hille, Rachel A. Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benítez, Lucia...
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Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate
Nature Neuroscience 2023, 26, 226–238 J Villadiego, J García-Arriaza, Reposo Ramírez-Lorca, R García-Swinburn, D Cabello-Rivera, AE. Rosales-Nieves, MI. Álvarez-Vergara, FCala-Fernández, E García-Roldán, JL. López-Ogáyar, C Zamora, D Astorgano, G...
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JAZ is essential for ligand specificity of the COI1/JAZ co-receptor
Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2212155119. I Monte, J Caballero, AM Zamarreño, G Fernández-Barbero, JM García-Mina, R Solano Abstract Jasmonates are phytohormones that regulate defense and developmental processes in land plants. Despite...
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SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes
Nucleic Acids Res. 2022 Nov 24;gkac1059. E Martínez-García, S Fraile, E Algar, T Aparicio, E Velázquez, Be Calles, H Tas, B Blázquez, B Martín, C Prieto, L Sánchez-Sampedro, MHH Nørholm, DC Volke, NT Wirth, P Dvořák, L Alejaldre, L Grozinger, M...
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Rearranged endogenized plant pararetroviruses as evidence of heritable RNA-based immunity
Mol Biol Evol. 2022 Nov 2;msac240. AA Valli, I Gonzalo-Magro, DH Sanchez Abstract Eukaryotic genomics frequently revealed historical spontaneous endogenization events of external invading nucleic acids, such as viral elements. In plants, an extensive...
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Within-patient evolution of plasmid-mediated antimicrobial resistance
Nat Ecol Evol. 2022 Oct 27. J de la Fuente, L Toribio-Celestino, A Santos-Lopez, R León-Sampedro, A Alonso-Del Valle, C Costas, M Hernández-García, L Cui, J Rodríguez-Beltrán, D Bikard, R Cantón, Alvaro San Millan Abstract Antimicrobial resistance...