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Early cortical GABAergic interneurons determine the projection patterns of L4 excitatory neurons
Sci Adv. 2024 May 10;10(19):eadj9911. Bragg-Gonzalo L, Aguilera A, González-Arias C, De León Reyes NS, Sánchez-Cruz A, Carballeira P, Leroy F, Perea G, Nieto M Abstract During cerebral cortex development, excitatory pyramidal neurons (PNs) establish...
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Synergism between remdesivir and ribavirin leads to SARS-CoV-2 extinction in cell culture
Br J Pharmacol. 2024 Apr 14. García-Crespo C, de Ávila AI, Gallego I, Soria ME, Durán-Pastor A, Somovilla P, Martínez-González B, Muñoz-Flores J, Mínguez P, Salar-Vidal L, Esteban-Muñoz M, Cañar-Camacho E, Ferrer-Orta C, Zuñiga S, Sola I, Enjuanes L,...
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Advancing the allergenicity assessment of new proteins using a text mining resource
Food Chem Toxicol. 2024 Apr 4;187:114638. Novoa J, Fernandez-Dumont A, Mills ENC, Moreno FJ, Pazos F. Abstract With a society increasingly demanding alternative protein food sources, new strategies for evaluating protein safety issues, such as...
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The trichome pattern diversity of Cardamine shares genetic mechanisms with Arabidopsis but differs in environmental drivers
Plant Physiol. 2024 Apr 12:kiae213. Fuster-Pons A, Murillo-Sánchez A, Méndez-Vigo B, Marcer A, Pieper B, Torres-Pérez R, Oliveros JC, Tsiantis M, Picó FX, Alonso-Blanco C. Abstract Natural variation in trichome pattern (amount and distribution) is...
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CoMentG: comprehensive retrieval of generic relationships between biomedical concepts from the scientific literature.
Database (Oxford). 2024 Apr 2;2024:baae025. Novoa J, López-Ibáñez J, Chagoyen M, Ranea JAG, Pazos F. Abstract The CoMentG resource contains millions of relationships between terms of biomedical interest obtained from the scientific literature. At the...
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Progressive alterations in polysomal architecture and activation of ribosome stalling relief factors in a mouse model of Huntington's disease
Neurobiol Dis. 2024 Mar 31;195:106488. Martin-Solana E, Diaz-Lopez I, Mohamedi Y, Ventoso I, Fernandez JJ, Fernandez-Fernandez MR. Abstract Given their highly polarized morphology and functional singularity, neurons require precise spatial and temporal...
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Refinement of paramagnetic bead-based digestion protocol for automatic sample preparation using an artificial neural network.
Talanta . 2024 Mar 23:274:125988 Ciordia S, Santos FM, Dias JML, Lamas JR, Paradela A, Alvarez-Sola G, Ávila MA, Corrales F. Abstract Despite technological advances in the proteomics field, sample preparation still represents the main bottleneck in...
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Mutant noxy8 exposes functional specificities between the chloroplast chaperones CLPC1 and CLPC2 in the response to organelle stress and plant defence
Plant Cell Environ . 2024 Mar 18. López B, Izquierdo Y, Cascón T, Zamarreño ÁM, García-Mina JM, Pulido P, Castresana C. Abstract Chloroplast function is essential for growth, development, and plant adaptation to stress. Organelle stress and plant...
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A model-driven approach to upcycling recalcitrant feedstocks in Pseudomonas putida by decoupling PHA production from nutrient limitation
Cell Rep. 2024 Mar 21;43(4):113979 Manoli MT, Gargantilla-Becerra Á, Del Cerro Sánchez C, Rivero-Buceta V, Prieto MA, Nogales J Abstract Bacterial polyhydroxyalkanoates (PHAs) have emerged as promising eco-friendly alternatives to petroleum-based...
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Microbiome changes through the ontogeny of the marine sponge Crambe crambe
Environ Microbiome . 2024 Mar 11;19(1):15. Turon M, Ford M, Maldonado M, Sitjà C, Riesgo A, Díez-Vives C Abstract Background: Poriferans (sponges) are highly adaptable organisms that can thrive in diverse marine and freshwater environments due, in...
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Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids
J Proteome Res. 2024 Mar 15 Blázquez-García I, Guerrero L, Cacho-Navas C, Djouder N, Millan J, Paradela A, Carmona-Rodríguez L, Corrales FJ Abstract MDR3 (multidrug resistance 3) deficiency in humans (MDR2 in mice) causes progressive familial...
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Modulating the immune response to SARS-CoV-2 by different nanocarriers delivering an mRNA expressing trimeric RBD of the spike protein: COVARNA Consortium
NPJ Vaccines. 2024 Mar 6;9(1):53. L Marcos-Villar # , B Perdiguero # , .... M Esteban, CE Gómez Abstract Vaccines based on mRNA technology have revolutionized the field. In fact, lipid nanoparticles (LNP) formulated with mRNA are the preferential...
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Elevated levels of cell-free NKG2D-ligands modulate NKG2D surface expression and compromise NK cell function in severe COVID-19 disease
Front Immunol. 2024 Feb 12:15:1273942. D Fernández-Soto, AF García-Jiménez, JM Casasnovas, M Valés-Gómez, HT Reyburn Introduction: It is now clear that coronavirus disease 19 (COVID-19) severity is associated with a dysregulated immune response, but...
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High compositional and functional similarity in the microbiome of deep-sea sponges
The ISME Journal Volume 18, Issue 1, January 2024 C Díez-Vives and A Riesgo Abstract Sponges largely depend on their symbiotic microbes for their nutrition, health, and survival. This is especially true in high microbial abundance (HMA) sponges, where...
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A tuneable genetic switch for tight control of tac promoters in Escherichia coli boosts expression of synthetic injectisomes
Microbial Biotechnology A Asensio-Calavia, A Ceballos-Munuera, A Méndez-Pérez, B Álvarez, LA Fernández Abstract Biosafety of engineered bacteria as living therapeutics requires a tight regulation to control the specific delivery of protein effectors,...
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Molecular basis of progressive familial intrahepatic cholestasis 3. A proteomics study
Biofactors L Guerrero, L Carmona-Rodríguez, F Milhano Santos, S Ciordia, L Stark, L Hierro, P Pérez-Montero, D Vicent, FJ Corrales Abstract Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a severe rare liver disease that affects between...
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SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
Cellular & Molecular Biology Letters R Seoane, T Lama-Díaz, AM Romero, A El Motiam, A Martínez-Férriz, S Vidal, YH Bouzaher, M Blanquer, RM Tolosa, J Castillo Mewa, MS Rodríguez, A García-Sastre, D Xirodimas, JD Sutherland, R Barrio, P Alepuz, MG...
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Feedback control of organ size precision is mediated by BMP2-regulated apoptosis in the Drosophila eye
PLOS Biology January 30, 2024 T Navarro, A Lannini, M Neto, A Campoy-Lopez, J Muñoz-García, P S. Pereira, S Ares, F Casares Abstract Biological processes are intrinsically noisy, and yet, the result of development—like the species-specific size and...
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DIDO is necessary for the adipogenesis that promotes diet-induced obesity
Proceedings of the National Academy of Sciences (PNAS) María Ángeles García-López, Alfonso Mora, Patricia Corrales, Tirso Pons, Ainhoa, Sánchez de Diego, Amaia Talavera Gutiérrez, Karel H. M. van Wely, Gema Medina-Gómez, Guadalupe Sabio, Carlos...
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DMSA-coated IONPs trigger oxidative stress, mitochondrial metabolic reprograming and changes in mitochondrial disposition, hindering cell cycle progression of cancer cells
Biomaterials Volume 304 , January 2024, 122409 Neus Daviu, Yadileiny Portilla, Marta Gómez de Cedrón, Ana Ramírez de Molina, Domingo F. Barber. Abstract There is increasing interest in modulating the redox homeostasis of tumors since high levels of...