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Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron
Front. Immunol., 25 April 2022 José M. Casasnovas, Yago Margolles, María A. Noriega, María Guzmán, Rocío Arranz, Roberto Melero, Mercedes Casanova, Juan Alberto Corbera, Nereida Jiménez-de-Oya, Pablo Gastaminza, Urtzi Garaigorta, Juan Carlos Saiz,...
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Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA
PNAS 2022; 119 (15) e2112376119 Silvia Hormeño, Oliver J, Wilkinson, Clara Aicart-Ramos, Sahiti Kuppa, Edwin Antony, Mark S. Dillingham, and Fernando Moreno-Herrero. Abstract Human DNA helicase B (HELB) is a poorly characterized helicase suggested to...
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Mutational background influences P. aeruginosa ciprofloxacin resistance evolution but preserves collateral sensitivity robustness
Proceedings of the National Academy of Sciences 2022 ; 119 (15) e2109370119 Sara Hernando-Amado, Pablo Laborda, José Ramón Valverde, and José Luis Martínez Abstract Collateral sensitivity is an evolutionary trade-off whereby acquisition of the adaptive...
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Spatial control of potato tuberization by the TCP transcription factor BRANCHED1b
Nat Plants. 2022 Mar;8(3):281-294. Michael Nicolas, Rafael Torres-Pérez, Vanessa Wahl, Eduard Cruz-Oró, María Luisa Rodríguez-Buey, Angel María Zamarreño, Beatriz Martín-Jouve, José María García-Mina, Juan Carlos Oliveros, Salomé Prat, Pilar Cubas...
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Differential environmental and genomic architectures shape the natural diversity for trichome patterning and morphology in different Arabidopsis organs
Plant Cell Environ. 2022 Mar 15. Noelia Arteaga, Belén Méndez-Vigo, Alberto Fuster-Pons, Marija Savic, Alba Murillo-Sánchez, F Xavier Picó, Carlos Alonso-Blanco Abstract Despite the adaptive and taxonomic relevance of the natural diversity for trichome...
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Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis
PLoS Pathog. 2022 Mar 9;18(3):e1010322. eCollection 2022 Mar. P Ortega-Gonzalez, G Taylor, RK Jangra, R Tenorio, I Fernandez de Castro, BA Mainou, RC Orchard, CB Wilen, PH Brigleb , J Sojati, K Chandran, M Sachse, C Risco, TS Dermody Abstract...
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Rapid decline of ceftazidime resistance in antibiotic-free and sub-lethal environments is contingent on genetic background.
Molecular Biology and Evolution ,15 March 2022 msac049 S Hernando-Amado, P Laborda, J Valverde, JL Martínez. Abstract Trade-offs of antibiotic resistance evolution, such as fitness cost and collateral sensitivity, could be exploited to drive evolution...
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The RecD2 helicase balances RecA activities
Nucleic Acids Res. 2022 Mar 2; C Ramos, R Hernández-Tamayo, M López-Sanz, B Carrasco, E Serrano, JC Alonso, PL Graumann, S Ayora Abstract DNA helicases of the RecD2 family are ubiquitous. Bacillus subtilis RecD2 in association with the single-stranded...
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Contribution of Host miRNA-223-3p to SARS-CoV-Induced Lung Inflammatory Pathology
mBio. 2022 Mar 1;e0313521. L Morales, JC Oliveros, L Enjuanes, I Sola Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV) and the closely related SARS-CoV-2 are emergent highly pathogenic human respiratory viruses causing acute lethal...
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Role of Nrp1 in controlling cortical inter-hemispheric circuits
Elife. 2022 Mar 1;11:e69776. F Martín-Fernández, A Bermejo-Santos, L Bragg-Gonzalo, CG Briz, E Serrano-Saiz, M Nieto Abstract Axons of the corpus callosum (CC) mediate the interhemispheric communication required for complex perception in mammals. In...
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Unraveling the antiviral activity of plitidepsin by subcellular and morphological analysis
Antiviral Res. 2022 Feb 26;105270 M Sachse, R Tenorio, I Fernández de Castro, J Muñoz-Basagoiti, D Perez-Zsolt, D Raïch-Regué, J Rodon, A Losada, P Avilés, C Cuevas, R Paredes, J Segalés, B Clotet, J Vergara-Alert, N Izquierdo-Useros, C Risco Abstract...
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Maf/ham1-like pyrophosphatases of non-canonical nucleotides are host-specific partners of viral RNA-dependent RNA polymerases
PLoS Pathog. 2022 Feb 18;18(2):e1010332. AA Valli, R García López, M Ribaya, FJ Martínez, D García Gómez, B García, I Gonzalo, A Gonzalez de Prádena, F Pasin, I Montanuy, E Rodríguez-Gonzalo, JA García Abstract Cassava brown streak disease (CBSD),...
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Full efficacy and long-term immunogenicity induced by the SARS-CoV-2 vaccine candidate MVA-CoV2-S in mice
NPJ Vaccines. 2022 Feb 9;7(1):17. A Lázaro-Frías, P Pérez, C Zamora PJ Sánchez-Cordón, M Guzmán, J Luczkowiak, R Delgado, JM Casasnovas, M Esteban, J García-Arriaza Abstract Two doses of the MVA-CoV2-S vaccine candidate expressing the SARS-CoV-2 spike...
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A simple immunoassay for extracellular vesicle liquid biopsy in microliters of non-processed plasma
J Nanobiotechnology. 2022 Feb 8;20(1):72 . C Campos-Silva, Y Cáceres-Martell, E Sánchez-Herrero, A Sandúa, A Beneitez-Martínez, A González, M Provencio, A Romero, R Jara-Acevedo, M Yáñez-Mó, MValés-Gómez Abstract Background: Extracellular vesicles...
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Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling
PLoS Pathog. 2022 Jan 25;18(1):e1010241. SB Hernández, S Castanheira, MG Pucciarelli JJ Cestero, G Rico-Pérez, A Paradela, JA Ayala, S Velázquez, A San-Félix, F Cava, F García-Del Portillo Abstract Salmonella enterica causes intracellular infections...
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The surface coating of iron oxide nanoparticles drives their intracellular trafficking and degradation in endolysosomes differently depending on the cell type
Biomaterials. 2022 Jan 6;281:121365. Y Portilla, V Mulens-Arias, A Paradela, A Ramos-Fernández, S Pérez-Yagüe, MP Morales, DF Barber Abstract Magnetic nanoparticles (MNPs) are potential theranostic tools that are biodegraded through different endocytic...
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M&Ms: A versatile software for building Microbial Mock communities
Bioinformatics. 2022 Jan 12;btab882. N García-García, J Tamames, F Puente-Sánchez Abstract Summary: Advances in sequencing technologies have triggered the development of many bioinformatic tools aimed to analyze 16S rDNA sequencing data. As these tools...
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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
Nat Commun. 2022 Jan 10;13(1):74. MT Bueno-Carrasco, J Cuéllar, MI Flydal, C Santiago, TA Kråkenes, R Kleppe, JR López-Blanco, M Marcilla, K Teigen , S Alvira, P Chacón, A Martinez, JM Valpuesta Abstract Tyrosine hydroxylase (TH) catalyzes the...
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The combined vaccination protocol of DNA/MVA expressing Zika virus structural proteins as efficient inducer of T and B cell immune responses
Emerg Microbes Infect. 2021 Dec;10(1):1441-1456. P Pérez, MA Martín-Acebes, T Poderoso, A Lázaro-Frías, JC Saiz, CÓS Sorzano, M Esteban, J García-Arriaza Abstract Zika virus (ZIKV) is a mosquito-borne pathogen with public health importance due to the...
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Translational demand is not a major source of plasmid-associated fitness costs
Philos Trans R Soc Lond B Biol Sci. 2022 Jan 17;377(1842):20200463. J Rodríguez-Beltrán, R León-Sampedro, P Ramiro-Martínez, C de la Vega, F Baquero, BR Levin, A San Millán Abstract Plasmids are key drivers of bacterial evolution because they are...