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Deletion of the vaccinia virus N2L gene encoding an inhibitor of IRF3 improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens
J Virol. 2014; 88(6): 3392-3410. García-Arriaza J, Gómez CE, Sorzano CÓ, Esteban M . A modified vaccinia virus Ankara poxvirus vector expressing the HIV-1 Env, Gag, Pol, and Nef antigens from clade B (MVA-B) is currently being tested in clinical...
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Nanovesicles are secreted during pollen germination and pollen tube growth: A possible role in fertilization
Mol Plant. 2014; 7(3): 573-577. Prado N, Alché Jde D, Casado-Vela J , Mas S, Villalba M, Rodríguez R, Batanero E. During recent decades, a novel mechanism of secretion has been identified in a wide range of mammalian cells. It involves the release of...
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Strigolactone promotes degradation of DWARF14, an α/β hydrolase essential for strigolactone signaling in Arabidopsis
Plant Cell. 2014; tpc.114.122903. Chevalier F, Nieminen K, Sánchez-Ferrero JC, Rodríguez ML, Chagoyen M, Hardtke CS, Cubas P . Strigolactones (SLs) are phytohormones that play a central role in regulating shoot branching. SL perception and signaling...
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The differential response of the Pben promoter of Pseudomonas putida mt-2 to BenR and XylS prevents metabolic conflicts in m-xylene biodegradation
Environ Microbiol. 2014; Mar 3. Pérez-Pantoja D1, Kim J, Silva-Rocha R, de Lorenzo V . Pseudomonas putida mt-2 encompasses two alternative and potentially conflicting routes for benzoate metabolism, one meta pathway encoded by xyl genes of the pWW0...
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Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors
Cell. 2014; 156(3): 577-589. Boer DR, Freire-Rios A, van den Berg WA, Saaki T, Manfield IW, Kepinski S, López-Vidrieo I, Franco-Zorrilla JM , de Vries SC, Solano R , Weijers D, Coll M. Auxin regulates numerous plant developmental processes by...
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PIFs get BRright: PHYTOCHROME INTERACTING FACTORs as integrators of light and hormonal signals
New Phytol. 2014; 202 (4): 1126-1141. de Lucas M, Prat S . Light and temperature, in coordination with the endogenous clock and the hormones gibberellin (GA) and brassinosteroids (BRs), modulate plant growth and development by affecting the expression...
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The bacterial effector HopX1 targets JAZ transcriptional repressors to activate jasmonate signaling and promote infection in Arabidopsis
PLoS Biol. 2014; 12(2): e1001792. Gimenez-Ibanez S, Boter M, Fernández-Barbero G, Chini A, Rathjen JP, Solano R . Pathogenicity of Pseudomonas syringae is dependent on a type III secretion system, which secretes a suite of virulence effector proteins...
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Flowering and tuberization: a tale of two nightshades
Trends Plant Sci. 2014; 19(2): 115-122. Abelenda JA, Navarro C, Prat S . The concept of florigen, postulated in the early 1930s, has taken form after the identification of the FLOWERING LOCUS T (FT) protein as the flowering-inducing signal. Besides...
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Deciphering the adjustment between environment and life history in annuals: Lessons from a geographically-explicit approach in Arabidopsis thaliana
PLoS One. 2014; 9(2): e87836. Manzano-Piedras E, Marcer A, Alonso-Blanco C , Picó FX. The role that different life-history traits may have in the process of adaptation caused by divergent selection can be assessed by using extensive collections of...
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Interkingdom signaling and its consequences for human health
Virulence. 2014; 5(2). Martínez JL . Quorum sensing (QS) is a cell density-dependent system of bacterial communication used by several species for triggering a coordinated response when the population reaches a given cell density threshold. Basically,...
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Evaluation of homo- and hetero-functionally activated glass surfaces for optimized antibody arrays
Anal Biochem. 2014; 450C: 37-45. González-González M, Bartolome R, Jara-Acevedo R, Casado-Vela J , Dasilva N, Matarraz S, García J, Alcazar JA, Sayagues JM, Orfao A, Fuentes M. Antibody arrays hold great promise for biomedical applications, but they...
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Increased diversity of the HLA-B40 ligandome by the presentation of peptides phosphorylated at their main anchor residue
Mol Cell Proteomics. 2014; 13(2): 462-474. Marcilla M, Alpízar A, Lombardía M, Ramos-Fernandez A, Ramos M, Albar JP . Human leukocyte antigen (HLA) class I molecules bind peptides derived from the intracellular degradation of endogenous proteins and...
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A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis
Breast Cancer Res. 2013; 15(6): R116. Van Impe K, Bethuyne J, Cool S, Impens F, Ruano-Gallego D, De Wever O, Vanloo B, Van Troys M, Lambein K, Boucherie C, Martens E, Zwaenepoel O, Hassanzadeh-Ghassabeh G, Vandekerckhove J, Gevaert K, Fernández LA ,...
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Jasmonate-dependent modifications of the pectin matrix during potato development function as a defense mechanism targeted by Dickeya dadantii virulence factors
Plant J. 2014; 77(3): 418-429. Taurino M, Abelenda JA, Río-Alvarez I, Navarro C, Vicedo B, Farmaki T, Jiménez P, García-Agustín P, López-Solanilla E, Prat S , Rojo E , Sánchez-Serrano JJ , Sanmartín M. The plant cell wall constitutes an essential...
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Rescue of infectious birnavirus from recombinant ribonucleoprotein complexes
PLoS One. 2014; 9(1): e87790. Dalton RM, Rodríguez JF . Birnaviruses are unconventional members of the icosahedral double-stranded (dsRNA) RNA virus group. The main differential birnavirus trait is the lack of the inner icosahedral transcriptional...
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DNA-binding specificities of plant transcription factors and their potential to define target genes
Proc Natl Acad Sci USA. 2014; 111(6): 2367-2372. Franco-Zorrilla JM , López-Vidriero I, Carrasco JL, Godoy M, Vera P, Solano R . Transcription factors (TFs) regulate gene expression through binding to cis-regulatory specific sequences in the promoters...
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CentrosomeDB: a new generation of the centrosomal proteins database for Human and Drosophila melanogaster
Nucleic Acids Res. 2014; 42(1): D430-D436. Alves-Cruzeiro JM, Nogales-Cadenas R, Pascual-Montano AD . We present the second generation of centrosomeDB, available online at http://centrosome.cnb.csic.es , with a significant expansion of 1357 human and...
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Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10
Proteins. 2014; 82 Suppl 2: 26-42. Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini M, Burgin A, Chen C, Cochran FV, Craig TK, Das R, Fass D, Garcia-Doval C, Herzberg O, Lorimer D, Luecke H, Ma X, Nelson DC, van Raaij MJ , Rohwer F, Segall A,...
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Single amino acid changes in the 6K1-CI region can promote the alternative adaptation of Prunus- and Nicotiana-propagated Plum pox virus C isolates to either host
Mol Plant Microbe Interact. 2014; 27(2): 136-149. Calvo M, Malinowski T, García JA . Plum pox virus (PPV) C is one of the less common PPV strains and specifically infects cherry trees in nature. Making use of two PPV-C isolates that display different...
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The genetic structure of Arabidopsis thaliana in the south-western Mediterranean range reveals a shared history between North Africa and Southern Europe
BMC Plant Biol. 2014; 14(1): 17. Brennan AC, Méndez-Vigo B, Haddioui A, Martínez-Zapater JM, Picó FX, Alonso-Blanco C . Deciphering the genetic structure of Arabidopsis thaliana diversity across its geographic range provides the bases for elucidating...