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Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions
Acta Crystallogr D Biol Crystallogr. 2014; 70 (Pt 7): 1934-1943. Recacha R, Jiménez D, Tian L, Barredo R, Gahmberg CG, Casasnovas JM . Intercellular cell adhesion molecule-5 (ICAM-5) is a member of the ICAM subfamily that is exclusively expressed in...
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Cell activation-induced phosphoinositide 3-kinase alpha/beta dimerization regulates PTEN activity
Mol Cell Biol. 2014; 34 (18): 3359-3373. Pérez-García V, Redondo-Muñoz J, Kumar A, Carrera AC . The PI3K/PTEN (phosphoinositide 3-kinase/phosphatase and tensin homolog) pathway is one of the central routes that enhances cell survival, division and...
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Transcriptomic analysis of Prunus domestica undergoing hypersensitive response to plum pox virus infection
PLoS One. 2014; 9 (6): e100477. Rodamilans B, San León D, Mühlberger L, Candresse T, Neumüller M, Oliveros JC, García JA . Plum pox virus (PPV) infects Prunus trees around the globe, posing serious fruit production problems and causing severe economic...
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Activation of DREAM (Downstream Regulatory Element Antagonistic Modulator), a calcium-binding protein, reduces L-DOPA-induced dyskinesias in mice
Biol Psychiatry. 2014;. pii: S0006-3223(14)00224-8. Ruiz-DeDiego I, Mellstrom B, Vallejo M, Naranjo JR , Moratalla R. BACKGROUND: Previous studies have implicated the cyclic adenosine monophosphate/protein kinase A pathway as well as FosB and...
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Coronavirus reverse genetic systems: Infectious clones and replicons
Virus Res. 2014; pii: S0168-1702(14)00240-8. Almazán F, Sola I, Zuñiga S, Marquez-Jurado S, Morales L, Becares M, Enjuanes L . Coronaviruses (CoVs) infect humans and many animal species, and are associated with respiratory, enteric, hepatic, and...
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Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse
J Immunol. 2014; pii: 1400350. Suárez-Fueyo A, Rojas JM, Cariaga AE, García E, Steiner BH, Barber DF , Puri KD, Carrera AC . Systemic lupus erythematosus (SLE) is a human chronic inflammatory disease generated and maintained throughout life by...
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Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ
Mol Cell Proteomics. 2014; pii: mcp.M113.035709. Kleppe R, Rosati S, Jorge-Finnigan A, Alvira S, Ghorbani S, Haavik J, Valpuesta JM , Heck AJ, Martinez A. Phosphorylated tyrosine hydroxylase (TH) can form complexes with 14-3-3 proteins, resulting in...
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A novel role of the potyviral helper component proteinase contributes to enhance the yield of viral particles
J Virol. 2014; 88 (17): 9808-9818. Valli A, Gallo A, Calvo M, Pérez JD, García JA . The helper component proteinase (HCPro) is an indispensable, multifunctional protein from members of the genus Potyvirus and other viruses of the family Potyviridae....
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Interaction of branch migration translocases with the Holliday junction-resolving enzyme and their implications in Holliday junction resolution
J Biol Chem. 2014; 289 (25): 17634-17646. Cañas C, Suzuki Y, Marchisone C, Carrasco B, Freire-Benéitez V, Takeyasu K, Alonso JC , Ayora S . Double-strand break repair involves the formation of Holliday junction (HJ) structures that need to be resolved...
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Fructose 1-phosphate is the one and only physiological effector of the Cra (FruR) regulator of Pseudomonas putida
FEBS Open Bio. 2014; 4: 377-386. Chavarría M, Durante-Rodríguez G, Krell T, Santiago C, Brezovsky J, Damborsky J, de Lorenzo V . Fructose-1-phosphate (F1P) is the preferred effector of the catabolite repressor/activator (Cra) protein of the soil...
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The Crc protein inhibits the production of polyhydroxyalkanoates in Pseudomonas putida under balanced carbon/nitrogen growth conditions
Environ Microbiol. 2014; 16 (1): 278-290. La Rosa R, de la Peña F, Prieto MA, Rojo F . Pseudomonas putida synthesizes polyhydroxyalkanoates (PHAs) as storage compounds. PHA synthesis is more active when the carbon source is in excess and the nitrogen...
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The metabolic cost of flagellar motion in Pseudomonas putida KT2440
Environ Microbiol. 2014; 16 (1): 291-303. Martínez-García E, Nikel PI, Chavarría M, de Lorenzo V . Although the flagellar machinery of environmental bacteria endows cells with a phenomenal survival device, it also consumes much of the metabolic...
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LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
Br J Cancer. 2014; 110(8): 2123-2130. Tajuddin SM, Amaral AF, Fernández AF, Chanock S, Silverman DT, Tardón A, Carrato A, García-Closas M, Jackson BP, Toraño EG, Márquez M, Urdinguio RG, García-Closas R, Rothman N, Kogevinas M, Real FX, Fraga MF ,...
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Epigenetic alterations in endocrine-related cancer
Endocr Relat Cancer. 2014; pii: ERC-13-0070. Rodríguez-Rodero S, Delgado-Álvarez E, Fernandez AF, Fernandez-Morera JL, Menedez-Torre E, Fraga M . Aberrant epigenetics is a hallmark of cancer, and endocrine-related tumors are no exception. Recent...
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Short-sighted evolution of bacterial opportunistic pathogens with an environmental origin
Front Microbiol. 2014; 5: 239. Martínez JL . Evolution is frequently considered as a directional process in which the organisms do not return, after evolving, to a pre-evolved situation. However, there are occassions in which evolution follows a sort...
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Generation of replication-proficient influenza virus NS1 point mutants with interferon-hyperinducer phenotype
PLoS One. 2014; 9(6): e98668. Pérez-Cidoncha M, Killip MJ, Asensio VJ, Fernández Y, Bengoechea JA, Randall RE, Ortín J . The NS1 protein of influenza A viruses is the dedicated viral interferon (IFN)-antagonist. Viruses lacking NS1 protein expression...
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An unbiased genetic screen reveals the polygenic nature of the influenza virus anti-interferon response
J Virol. 2014; 88(9): 4632-4646. Pérez-Cidoncha M, Killip MJ, Oliveros JC, Asensio VJ, Fernández Y, Bengoechea JA, Randall RE, Ortín J . Influenza A viruses counteract the cellular innate immune response at several steps, including blocking RIG...
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Antitumor effects of a monoclonal antibody to human CCR9 in leukemia cell xenografts
mAbs. 2014; 6(1): 1002-1014. Chamorro S, Vela M, Franco-Villanueva A, Carramolino L, Gutiérrez J, Gómez L, Lozano M, Salvador B, García-Gallo M, Martínez-A C , Kremer L . Tumor expression of certain chemokine receptors is associated with resistance to...
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New insights into rotavirus entry machinery: stabilization of rotavirus spike conformation is independent of trypsin cleavage
PLoS Pathog. 2014; 10(5): e1004157. Rodríguez JM, Chichón FJ, Martín-Forero E, González-Camacho F, Carrascosa JL , Castón JR , Luque D. The infectivity of rotavirus, the main causative agent of childhood diarrhea, is dependent on activation of the...
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Synchronization dynamics in the presence of coupling delays and phase shifts
Phys Rev Lett. 2014; 112(17): 174101. Jörg DJ, Morelli LG, Ares S , Jülicher F. In systems of coupled oscillators, the effects of complex signaling can be captured by time delays and phase shifts. Here, we show how time delays and phase shifts lead to...