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Specific and non-specific interactions of ParB with DNA: implications for chromosome segregation
Nucleic Acids Res. 2015; pii: gku1295. Taylor JA, Pastrana CL, Butterer A, Pernstich C, Gwynn EJ, Sobott F, Moreno-Herrero F , Dillingham MS. The segregation of many bacterial chromosomes is dependent on the interactions of ParB proteins with...
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Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production
Sci Rep. 2015; 5: 7691. Daszkiewicz L, Vázquez-Mateo C, Rackov G, Ballesteros-Tato A, Weber K, Madrigal-Avilés A, Di Pilato M, Fotedar A, Fotedar R, Flores JM, Esteban M , Martínez-A C , Balomenos D . Self/non-self discrimination characterizes immunity...
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Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins
Oncotarget. 2014; Dec 18. Vilas JM, Ferreirós A, Carneiro C, Morey L, Da Silva-Álvarez S, Fernandes T, Abad M, Di Croce L, García-Caballero T, Serrano M, Rivas C , Vidal A, Collado M. Cellular reprogramming to iPSCs has uncovered unsuspected links...
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INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community
Nucleic Acids Res. 2015; 43 (Database issue): D1171-5. Meehan TF, Chen CK, Koscielny G, Relac M, Wilkinson P, Flicek P, Parkinson H, Castro A, Fessele S, Steinkamp R, Hagn M, Raess M, de Angelis MH, Bottomley J, Ramirez-Solis R, Smedley D, Ball S,...
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Methods to Immobilize GPCR on the Surface of SPR Sensors
Methods Mol Biol. 2015; 1272: 173-188. Martínez-Muñoz L, Barroso R, Paredes AG, Mellado M , Rodríguez-Frade JM. The G protein-coupled receptors (GPCRs) form one of the largest membrane receptor families. The nature of the ligands that interact with...
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Molecular locks and keys: the role of small molecules in phytohormone research
Front Plant Sci. 2014; 5: 709. Fonseca S, Rosado A, Vaughan-Hirsch J, Bishopp A, Chini A . Plant adaptation, growth and development rely on the integration of many environmental and endogenous signals that collectively determine the overall plant...
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Emergence and spread of antibiotic resistance: setting a parameter space
Ups J Med Sci. 2014; 119 (2): 68-77. Martínez JL , Baquero F. The emergence and spread of antibiotic resistance among human pathogens is a relevant problem for human health and one of the few evolution processes amenable to experimental studies. In the...
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Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases
J Biol Chem. 2014; 289 (33):22614-22629. López-Perrote A, Alatwi HE, Torreira E, Ismail A, Ayora S , Downs JA, Llorca O. Yin Yang 1 (YY1) is a transcription factor regulating proliferation and differentiation and is involved in cancer development....
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Crystal structure of the fibre head domain of the atadenovirus Snake Adenovirus 1
PLoS One. 2014; 9 (12): e114373. Singh AK, Menéndez-Conejero R, San Martín C , van Raaij MJ . Adenoviruses are non-enveloped icosahedral viruses with trimeric fibre proteins protruding from their vertices. There are five known genera, from which only...
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Rewiring of genetic networks in response to modification of genetic background
Genome Biol Evol. 2014; 6 (12): 3267-3280. Bajić D, Moreno C, Poyatos JF . Genome-scale genetic interaction networks are progressively contributing to map the molecular circuitry that determines cellular behaviour. To what extent this mapping changes...
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Cancer stem cell-like phenotype and survival are coordinately regulated by Akt/FoxO/Bim pathway
Stem Cells. 2014; doi: 10.1002/stem.1904. Gargini R, Cerliani JP, Escoll M, Antón IM , Wandosell F. Many solid tumors contain a subpopulation of cells with stem characteristics and these known as cancer stem cell (CSCs) or tumor-initiating cells...
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Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop
Nat Commun. 2014; 5: 5484. Alvira S, Cuéllar J, Röhl A, Yamamoto S, Ito H, Alfonso CB, Rivas G, Buchner J, Valpuesta JM . In eukarya, chaperones Hsp70 and Hsp90 act coordinately in the folding and maturation of a range of key proteins with the help of...
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Probing DNA helicase kinetics with temperature-controlled magnetic tweezers
Small. 2014; doi: 10.1002/smll.201402686. Gollnick B, Carrasco C, Zuttion F, Gilhooly NS, Dillingham MS, Moreno-Herrero F . Motor protein functions like adenosine triphosphate (ATP) hydrolysis or translocation along molecular substrates take place at...
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The Listeria Small RNA Rli27 Regulates a Cell Wall Protein inside Eukaryotic Cells by Targeting a Long 5′-UTR Variant
PLoS Genet. 10 (10): e1004765. Quereda JJ, Ortega ÁD, Pucciarelli MG, García-del Portillo F . Listeria monocytogenes is a bacterial pathogen whose genome encodes many cell wall proteins that bind covalently to peptidoglycan. Some members of this...
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Arid3b is essential for second heart field cell deployment and heart patterning
Development. 2014; 141 (21): 4168-4181. Uribe V, Badía-Careaga C, Casanova JC, Domínguez JN, de la Pompa JL, Sanz-Ezquerro JJ . Arid3b , a member of the conserved ARID family of transcription factors, is essential for mouse embryonic development but...
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Plastic embedding of Arabidopsis stem sections
Bio-protocol. 2014; 4 (20): e1261. Chevalier F, Iglesias S M, Sánchez ÓJ, Montoliu L , Cubas P . The inflorescence stem of the flowering plant Arabidopsis thaliana (thale cress) is an excellent model system to investigate plant vascular tissue...
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Three-dimensional imaging of viral infections
Annu Rev Virol 2014; 1: 453-473. Risco C , Fernández de Castro I, Sanz-Sánchez L, Narayan K, Grandinetti G, Subramaniam S. ReThree-dimensional (3D) imaging technologies are beginning to have significant impact in the field of virology, as they are...
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Mouse Genome Editing Using the CRISPR/Cas System
Curr Protoc Hum Genet. 2014; 83:15.7.1-15.7.27. Harms DW, Quadros RM, Seruggia D, Ohtsuka M, Takahashi G, Montoliu L , Gurumurthy CB. The availability of techniques to create desired genetic mutations has enabled the laboratory mouse as an extensively...
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Pro-oncogenic role of alternative p38 mitogen-activated protein kinases p38γ and p38δ, linking inflammation and cancer in colitis-associated colon cancer
Cancer Res. 2014 Sep 12. pii: canres.0870.2014. Del Reino P, Alsina-Beauchamp D, Escós A, Cerezo-Guisado MI, Risco A, Aparicio N, Zur R, Fernandez-Estevez M, Collantes E, Montans J, Cuenda A . p38 mitogen-activated protein kinase (MAPK) signalling has...
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Effect of herbicide combinations on Bt-maize rhizobacterial diversity
J Microbiol Biotechnol. 2014; 24 (11): 1473-1783. Valverde JR, Marin S, Mellado RP . Reports of herbicide resistance events are proliferating worldwide leading to new cultivation strategies using combinations of pre-emergence and post-emergence...