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Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine
PLoS Pathog. 2015 Oct 29;11(10):e1005215. doi: 10.1371/journal.ppat.1005215. Jimenez-Guardeño JM , Regla-Nava JA, Nieto-Torres JL, DeDiego ML, Castaño-Rodriguez C, Fernandez-Delgado R, Perlman S, Enjuanes L.
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The keepers of the ring: regulators of FtsZ assembly
FEMS Microbiol Rev. 2015 Sep 15. pii: fuv040 Ortiz C., Natale P., Cueto L., and Vicente M. FtsZ, a GTPase distributed in the cytoplasm of most bacteria, is the major component of the machinery responsible for division (the divisome) in Escherichia...
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ESCRT-III-Associated Protein ALIX Mediates High Affinity Phosphate Transporter Trafficking to Maintain Phosphate Homeostasis in Arabidopsis
Plant Cell. 2015 Sep 4. pii: tpc.15.00393 Cardona-López X., Cuyas L. , Marín E., Rajulu C., Irigoyen M.L., Gil E., Puga M.I. , Bligny R., Nussaume L., Geldner N., Paz-Ares J., and Rubio V. Prior to the release of their cargoes into the vacuolar lumen,...
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Arabidopsis ALIX is required for the endosomal localization of the deubiquitinating enzyme AMSH3
Proc Natl Acad Sci U S A. 2015 Aug 31. pii: 201510516. Kalinowska K., Nagel M.K., Goodman K., Cuyas L., Anzenberger F., Alkofer A., Paz-Ares J. , Braun P., Rubio V. , Otegui M.S., Isono E. Ubiquitination is a signal for various cellular processes,...
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Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates
PLoS Pathog 2015 Aug 6;11(8):e1004977. doi: 10.1371/journal.ppat.1004977 Vidal E., Fernández-Borges N., Pintado B. , Eraña H., Ordóñez M., Márquez M., Chianini F., Fondevila D., Sánchez-Martín M.A., Andreoletti O., Dagleish M.P., Pumarola M., Castilla...
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The interaction of ω2 with the RNA polymerase β’ subunit functions as an activation to repression switch
Nucleic Acids Res. 2015 Aug 3. pii: gkv788 Volante A., Carrasco B., Tabone M. and Alonso J. C. The ω gene is encoded in broad-host range and low-copy plasmids. It is genetically linked to antibiotic resistance genes of the major human pathogens of...
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Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development
Leukemia. 2015 Jul 28. doi: 10.1038/leu.2015.202 Roncero A.M., López-Nieva P., Cobos-Fernández M.A., Villa-Morales M., González-Sánchez L., López-Lorenzo J.L., Llamas P., Ayuso C., Rodríguez-Pinilla S.M., María Del C.A., Piris M., Fernández-Navarro P.,...
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Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct
J. Am. Chem. Soc. 2015; DOI:0.1021/jacs.5b04080 Concepción González-Bello, Lorena Tizón, Emilio Lence, José M. Otero, Mark J. van Raaij , Marta Martinez-Guitian, Alejandro Beceiro, Paul Thompson and Alastair R. Hawkins. The first example of an ammonium...
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MIR retrotransposon sequences provide insulators to the human genome
PNAS, 2015 DOI:10.1073/pnas.1507253112 Jianrong Wang, Cristina Vicente-García, Davide Seruggia, Eduardo Moltó, Ana Fernandez-Miñán, Ana Neto, Elbert Lee, José Luis Gómez-Skarmeta, Lluís Montoliu V ictoria V. Lunyak, and I. King Jordan. Insulators are...
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A Recently Evolved Alternative Splice Site in the BRANCHED1a Gene Controls Potato Plant Architecture
Curr Biol. 2015 Jul 20;25(14):1799-809. doi: 10.1016/j.cub.2015.05.053 Nicolas M, Rodríguez-Buey ML, Franco-Zorrilla JM, and Cubas P Amplification and diversification of transcriptional regulators that control development is a driving force of...
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Chemical Modification of a Dehydratase Enzyme Involved in Bacterial Virulence by an Ammonium Derivative: Evidence of its Active Site Covalent Adduct
J. Am. Chem. Soc. 2015; DOI:0.1021/jacs.5b04080 Concepción González-Bello, Lorena Tizón, Emilio Lence, José M. Otero, Mark J. van Raaij , Marta Martinez-Guitian, Alejandro Beceiro, Paul Thompson and Alastair R. Hawkins. The first example of an ammonium...
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Bacillus subtilis RecO and SsbA are crucial for RecA-mediated recombinational DNA repair
Nucleic Acids Res. 2015 Jul 13;43(12):5984-97. doi: 10.1093/nar/gkv545 Carrasco B., Yadav T., Serrano E., and Alonso J.C . Genetic data have revealed that the absence of Bacillus subtilis RecO and one of the end-processing avenues (AddAB or RecJ)...
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Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8290-5. doi: 10.1073/pnas.1506538112. Garcia-Ferrer I., Arêde P., Gómez-Blanco J., Luque D., Duquerroy S., Castón J.R. , Goulas T., Gomis-Rüth F.X. The survival of commensal bacteria requires them to evade...
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Practical analysis of specificity-determining residues in protein families
Brief Bioinform. 2015 Jul 2. pii: bbv045 Chagoyen M, García-Martín JA, Pazos F
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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Proc Natl Acad Sci USA. 2015; pii: 201421204. Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM , Dobson CM,...
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Distribution of DNA-condensing protein complexes in the adenovirus core
Nucleic Acids Res. 2015; pii: gkv187. Pérez-Berná AJ, Marion S, Chichón FJ, Fernández JJ , Winkler DC, Carrascosa JL , Steven AC, Šiber A, San Martín C . Genome packing in adenovirus has long evaded precise description, since the viral dsDNA molecule...
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Global variability in gene expression and alternative splicing is modulated by mitochondrial content
Genome Res. 2015; pii: gr.178426.114. Guantes R, Rastrojo A, Pires das Neves R, Lima A, Aguado B, Iborra FJ . Noise in gene expression is a main determinant of phenotypic variability. Increasing experimental evidence suggests that genome-wide cellular...
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Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
Nucleic Acids Res. 2015; pii: gkv204. Morin JA, Cao FJ, Lázaro JM, Arias-Gonzalez JR, Valpuesta JM , Carrascosa JL , Salas M, Ibarra B. During DNA replication replicative polymerases move in discrete mechanical steps along the DNA template. To address...
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Endogenous Arabidopsis messenger RNAs transported to distant tissues
Nature Plants 2015; doi: 10.1038/nplants.2015.25. Thieme CJ, Rojas-Triana M, Stecyk E, Schudoma C, Zhang W, Yang L, Miñambres M, Walther D, Schulze WX, Paz-Ares J , Scheible WR, Kragler F. The concept that proteins and small RNAs can move to and...
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ELF3-PIF4 interaction regulates plant growth independently of the evening complex
Curr Biol. 2015; 25(2): 187-193. Nieto C, López-Salmerón V, Davière JM, Prat S . The circadian clock plays a pivotal role in the control of Arabidopsis hypocotyl elongation by regulating rhythmic expression of the bHLH factors PHYTOCHROME INTERACTING...