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Phosphoinositide 3-kinase beta protects nuclear envelope integrity by controlling RCC1 localization and Ran activity
Mol Cell Biol. 2015; 35 (1): 249-263. Redondo-Muñoz J, Pérez-García V, Rodríguez MJ, Valpuesta JM , Carrera AC . The nuclear envelope (NE) forms a barrier between the nucleus and the cytosol that preserves genomic integrity. The nuclear lamina and...
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Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly
PNAS. 2015; 112 (8): 2413-2418. Plimpton RL, Cuéllar J, Lai CW, Aoba T, Makaju A, Franklin S, Mathis AD, Prince JT, Carrascosa JL , Valpuesta JM , Willardson BM. G-protein signaling depends on the ability of the individual subunits of the G-protein...
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Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors
Blood. 2015; 125 (7). Gómez-Moutón C, Fischer T, Peregil RM, Jiménez-Baranda S, Stossel TP, Nakamura F, Mañes S . Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare congenital immunodeficiency often caused by...
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Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres
Nucleic Acids Res. 2015;. pii: gkv082. de Sena-Tomás C, Yu EY, Calzada A , Holloman WK, Lue NF, Pérez-Martín J. The Ku heterodimer serves in the initial step in repairing DNA double-strand breaks by the non-homologous end-joining pathway. Besides this...
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Attitude toward living kidney donation: differences between students from two spanish universities
Transplant Proc. 2015; 47 (1): 10-12. Martínez-Alarcón L, Ramis G, Gómez-Laguna J, Quereda JJ , Herrero-Medrano JM, Mrowiec A, Mendonça L, López-Navas A, Ríos A. Introduction: Due to the current deficit of organs for transplantation, living kidney...
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Irreversible covalent modification of type I dehydroquinase with a stable Schiff base
Org Biomol Chem. 2015; 13 (3): 706-716. Tizón L, Maneiro M, Peón A, Otero JM, Lence E, Poza S, van Raaij MJ , Thompson P, Hawkins AR, González-Bello C. The irreversible inhibition of type I dehydroquinase (DHQ1), the third enzyme of the shikimic acid...
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Alphavirus replicon DNA expressing HIV antigens is an excellent prime for boosting with recombinant modified vaccinia Ankara (MVA) or with HIV gp140 protein antigen
PLoS One. 2015; 10 (2): e0117042. Knudsen ML, Ljungberg K, Tatoud R, Weber J, Esteban M , Liljeström P. Vaccination with DNA is an attractive strategy for induction of pathogen-specific T cells and antibodies. Studies in humans have shown that DNA...
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Clathrin mediates infectious hepatitis C virus particle egress
J Virol. 2015; pii: JVI.03620-14. Benedicto I, Gondar V, Molina-Jiménez F, García-Buey L, López-Cabrera M, Gastaminza P , Majano PL. Although it is well established that hepatitis C virus (HCV) entry into hepatocytes depends on clathrin-mediated...
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New patterns in human biogeography revealed by networks of contacts between linguistic groups
Proc Biol Sci. 2015; 282 (1802). pii: 20142947. Capitán JA, Bock Axelsen J, Manrubia S . Human languages differ broadly in abundance and are distributed highly unevenly on the Earth. In many qualitative and quantitative aspects, they strongly resemble...
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Viral factors involved in plant pathogenesis
Curr Opin Virol. 2015; 11C: 21-30. García JA , Pallás V. Plant viruses must usurp host factors/routes for their survival. Disturbances derived from this extreme dependence for host resources, together with physiological alterations associated with...
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Plant embryogenesis requires AUX/LAX-mediated auxin influx
Development. 2015; pii: dev.115832. Robert HS, Grunewald W, Sauer M , Cannoot B, Soriano M, Swarup R, Weijers D, Bennett M, Boutilier K, Friml J. The plant hormone auxin and its directional transport are known to play a crucial role in defining the...
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DisA and c-di-AMP act at the intersection between DNA-damage response and stress homeostasis in exponentially growing Bacillus subtilis cells
DNA Repair. 2015; 27C: 1-8. Gándara C, Alonso JC . Bacillus subtilis contains two vegetative diadenylate cyclases, DisA and CdaA, which produce cyclic di-AMP (c-di-AMP), and one phosphodiesterase, GdpP, that degrades it into a linear di-AMP. We report...
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Interleukin 1- and type I interferon-dependent enhancement of the innate immune profile of a NYVAC-HIV-1 Env-Gag-Pol-Nef vaccine vector with dual deletion of type I and type II interferon-binding proteins
J Virol. 2015; pii: JVI.03061-14. Delaloye J, Filali-Mouhim A, Cameron MJ, Haddad EK, Harari A, Goulet JP, Gomez CE, Perdiguero B, Esteban M , Pantaleo G, Roger T, Sékaly RP, Calandra T. NYVAC, a highly attenuated, replication-restricted poxvirus, is a...
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SARS coronaviruses with mutations in E protein are attenuated and promising vaccine candidates
J Virol. 2015; pii: JVI.03566-14. Regla-Nava JA, Nieto-Torres JL, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodríguez C, Perlman S, Enjuanes L , DeDiego ML. Severe acute respiratory syndrome coronavirus (SARS-CoV) causes a respiratory...
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What is a resistance gene? Ranking risk in resistomes
Nat Rev Microbiol. 2015; 13 (2): 116-123. Martínez JL , Coque TM, Baquero F. Metagenomic studies have shown that antibiotic resistance genes are ubiquitous in the environment, which has led to the suggestion that there is a high risk that these genes...
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KSHV latent protein LANA2 inhibits SUMO2 modification of p53
Cell Cycle. 2015; 14 (2): 277-282. Laura MV, Cruz-Herrera CF, Ferreirós A, Baz-Martínez M, Lang V, Vidal A, Muñoz-Fontela C, Rodríguez MS, Collado M, Rivas C . Tumor suppressor p53 plays a crucial antiviral role and targeting of p53 by viral proteins...
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Practical Protein Bioinformatics
ISBN 978-3-319-12727-9. Florencio Pazos y Mónica Chagoyen . This book describes more than 60 web-accessible computational tools for protein analysis and is totally practical, with detailed explanations on how to use these tools and interpret their...
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Virological and immunological characterization of novel NYVAC-Based HIV/AIDS vaccine candidates expressing Clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles
J Virol. 2015; 89 (2): 970-988. Perdiguero B, Gómez CE, Cepeda V, Sánchez-Sampedro L, García-Arriaza J, Mejías-Pérez E, Jiménez V, Sánchez C, Sorzano CÓ, Oliveros JC, Delaloye J, Roger T, Calandra T, Asbach B, Wagner R, Kibler KV, Jacobs BL, Pantaleo...
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Structural basis for host membrane remodeling induced by Protein 2B of hepatitis A virus
J Virol. 2015; pii: JVI.02881-14. Vives-Adrián L, Garriga D , Buxaderas M, Fraga JS, Barbosa Pereira PJ, Macedo-Ribeiroand S, Verdaguer N. The complexity of viral RNA synthesis and the numerous participating factors require a mechanism to topologically...
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NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery
J Leukoc Biol. 2015; jlb.4A0714-326R. Spada R, Rojas JM, Pérez-Yagüe S, Mulens V, Cannata-Ortiz P, Bragado R, Barber DF . NK cells are a major component of the immune system, and alterations in their activity are correlated with various autoimmune...