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A function of the major quinolone resistance determinant of Stenotrophomonas maltophilia SmeDEF is the colonization of the roots of the plants
Appl Environ Microbiol. 2014; pii: AEM.01058-14. García-León G, Hernández A, Hernando-Amado S, Alavi P, Berg G, Martínez JL . Quinolones are synthetic antibiotics and the main cause of resistance to these antimicrobials is mutation of the genes...
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Sequence-specific interactions of Rep proteins with ssDNA in the AT-rich region of the plasmid replication origin
Nucleic Acids Res. 2014; 42 (12): 7807-7818. Wegrzyn K, Fuentes-Perez ME, Bury K, Rajewska M, Moreno-Herrero F , Konieczny I. The DNA unwinding element (DUE) is a sequence rich in adenine and thymine residues present within the origin region of both...
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Specific residues of PB2 and PA influenza virus polymerase subunits confer the ability for RNA polymerase II degradation and virus pathogenicity in mice
J Virol. 2014; 88(6): 3455-3463. Llompart CM, Nieto A , Rodriguez-Frandsen A. Influenza virus transcription requires functional coupling with cellular transcription for the cap-snatching process. Despite this fact, RNA polymerase II (RNAP II) is...
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Repression of jasmonate-dependent defenses by shade involves differential regulation of protein stability of MYC transcription factors and their JAZ repressors in Arabidopsis
Plant Cell. 2014, pii: tpc.114.125047. Chico JM, Fernández-Barbero G, Chini A, Fernández-Calvo P, Díez-Díaz M, Solano R . Reduction of the red/far-red (R/FR) light ratio that occurs in dense canopies promotes plant growth to outcompete neighbors but...
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Interplay between the mechanics of bacteriophage fibers and the strength
Phys. Rev. E 2014; 89: 052710. Ares P, Garcia-Doval C, Llauró A, Gómez-Herrero M, van Raaij MJ , de Pablo PJ. Viral fibers play a central role in many virus infection mechanisms since they recognize the corresponding host and establish a mechanical...
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T cells kill bacteria captured by transinfection from dendritic cells and confer protection in mice
Cell Host Microbe. 2014; 15: 611-622. Cruz-Adalia A, Ramirez-Santiago G, Calabia-Linares C, Torres-Torresano M, Feo L, Galán-Díez M, Fernández-Ruiz E, Pereiro E, Guttmann P, Chiappi M, Schneider G, Carrascosa JL , Chichón FJ, Martínez del Hoyo G,...
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The private life of environmental bacteria: pollutant biodegradation at the single cell level
Environ Microbiol. 2014; 16(3): 628-642. Nikel PI1, Silva-Rocha R, Benedetti I, de Lorenzo V . Bacteria display considerable cell-to-cell heterogeneity in a number of genetic and physiological traits. Stochastic differences in regulatory patterns (e.g....
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Probing the free energy landscape of the fast-folding gpW protein by relaxation dispersion NMR
J Am Chem Soc. 2014; doi: 10.1021/ja502705y. Sanchez-Medina C, Sekhar A, Vallurupalli P, Cerminara M, Muñoz V , Kay LE. The topographic features of the free energy landscapes that govern the thermodynamics and kinetics of conformational transitions in...
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Cryo-EM near-atomic structure of a dsRNA fungal virus shows ancient structural motifs preserved in the dsRNA viral lineage
PNAS. 2014; 111: 7641-7646. Luque D, Gómez-Blanco J, Garriga D, Brilot AF, González JM, Havens WM, Carrascosa JL , Trus BL, Verdaguer N, Ghabrial SA, Castón JR . Viruses evolve so rapidly that sequence-based comparison is not suitable for detecting...
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TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity
Immunity. 2014; 40(4): 542-553. Angiari S, Donnarumma T, Rossi B, Dusi S, Pietronigro E, Zenaro E, Della Bianca V, Toffali L, Piacentino G, Budui S, Rennert P, Xiao S, Laudanna C, Casasnovas JM , Kuchroo VK, Constantin G. Selectins play a central role...
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SUMOylation regulates AKT1 activity
Oncogene. 2014;. doi: 10.1038/onc.2014.48. de la Cruz-Herrera CF, Campagna M, Lang V, Del Carmen González-Santamaría J, Marcos-Villar L, Rodríguez MS, Vidal A, Collado M, Rivas C . Serine threonine kinase AKT has a central role in the cell, controlling...
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WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes
Hum Mol Genet. 2014; doi: 10.1093/hmg/ddu155. Franco-Villanueva A, Fernández-López E, Gabandé-Rodríguez E, Bañón-Rodríguez I, Esteban JA, Antón IM , Ledesma MD. We identify Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) as a novel...
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Enhancing poxvirus vectors vaccine immunogenicity
Hum Vaccin Immunother. 2014; 10(8). García-Arriaza J, Esteban M . Attenuated recombinant poxvirus vectors expressing heterologous antigens from pathogens are currently at various stages in clinical trials with the aim to establish their efficacy. This...
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The Crc and Hfq proteins of Pseudomonas putida co-operate in catabolite repression and formation of RNA complexes with specific target motifs
Environ Microbiol. 2014; doi: 10.1111/1462-2920.12499. Moreno R, Hernández-Arranz S, La Rosa R, Yuste L, Madhushani A, Shingler V, Rojo F . The Crc protein is a global regulator that has a key role in catabolite repression and optimization of...
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Binding of the WASP/N-WASP interacting protein WIP to actin regulates focal adhesion assembly and adhesion
Mol Cell Biol. 2014; May 5. Ramesh N, Massaad MJ, Kumar L, Suresh K, Sasahara Y, Anton I , Bhasin M, Libermann T, Geha R. The actin cytoskeleton is essential for cell adhesion and migration, functions important for tumor invasion. In addition to...
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Evaluation of the single cervical skin test and interferon gamma responses to detect Mycobacterium bovis infected cattle in a herd co-infected with Mycobacterium avium subsp. paratuberculosis
Vet Microbiol. 2014; pii: S0378-1135(14)00185-0. Seva J, Sanes JM, Ramis G, Mas A, Quereda JJ , Villarreal-Ramos B, Villar D, Pallares FJ. This study reports the performance of the single intradermal tuberculin (SIT) test and the interferon-gamma...
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Severe Acute Respiratory Syndrome Coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis
PLoS Pathog. 2014; 10(5): e1004077. Nieto-Torres JL, Dediego ML, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Castaño-Rodriguez C, Alcaraz A, Torres J, Aguilella VM, Enjuanes L . Deletion of Severe Acute Respiratory...
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Metabolic compensation of fitness costs associated to the overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa
Antimicrob Agents Chemother. 2014; Apr 28. Olivares Pacheco J, Alvarez-Ortega C, Martinez JL . The acquisition of antibiotic resistance has been associated to a possible non-specific, metabolic burden that is reflected in a decrease in fitness among...
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CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface
Proc Natl Acad Sci USA. 2014; 111 (19): E1960-9. Martínez-Muñoz L, Barroso R, Dyrhaug SY, Navarro G, Lucas P, Soriano SF, Vega B, Costas C, Muñoz-Fernández MA, Santiago C, Frade JM, Franco R, Mellado M . CCR5 and CXCR4, the respective cell surface...
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Modulation of the hsp90 chaperone cycle by a stringent client protein
Mol Cell. 2014; 53(6): 941-953. Lorenz OR, Freiburger L, Rutz DA, Krause M, Zierer BK, Alvira S, Cuéllar J, Valpuesta JM , Madl T, Sattler M, Buchner J. Hsp90 is the most abundant molecular chaperone in the eukaryotic cell. One of the most stringent...