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Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation
Immunological Reviews Domínguez PM & Ardavín C Although monocytes were originally described as precursors to all the different subpopulations of macrophages found in the steady state and formed under inflammatory and infectious conditions, recent data...
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Arabidopsis thaliana as a model for the study of plant-virus co-evolution
Philos Trans R Soc Lond B Biol Sci Pagán I, Fraile A , Fernandez-Fueyo E, Montes N, Alonso-Blanco C & García-Arenal F. Understanding plant-virus coevolution requires wild systems in which there is no human manipulation of either host or virus. To...
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cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
Trends in Biochemical Sciences Sabio G & Davis RJ. The cJun NH 2 -terminal kinase isoform JNK1 is implicated in the mechanism of obesity-induced insulin resistance. Feeding a high-fat diet causes activation of the JNK1 signaling pathway, insulin...
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An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells
The FASEB Journal Mañes S , Fuentes G, Peregil RM, Rojas AM & Lacalle RA. Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5KI)- participates in establishing polarity during leukocyte chemotaxis. Its final 83 amino acids localize PIP5KI to the...
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A toxin-antitoxin module as a target for antimicrobial development
Plasmid Lioy VS, Rey O, Balsa D, Pellicer T & Alonso JC . The emergence and spread of pathogenic bacteria that have become resistant to multiple antibiotics through lateral gene transfer have created the need of novel antimicrobials. Toxin–antitoxin...
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Temporal analysis of natural variation for the rate of leaf production and its relationship with flowering initiation in Arabidopsis thaliana
Journal of Experimental Botany Méndez-Vigo B, Andrés MT, Ramiro M, Martínez-Zapater JM & Alonso-Blanco C . Vegetative growth and flowering initiation are two crucial developmental processes in the life cycle of annual plants that are closely...
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Differential activation of p38MAPK isoforms by MKK6 and MKK3
Cellular Signalling Remy G, Risco AM, Iñesta-Vaquera FA, González-Terán B, Sabio G , Davis RJ, Cuenda A . All four members of the mammalian p38 mitogen-activated protein kinase (MAPK) family (p38alpha, p38beta, p38gamma and p38delta) are activated by...
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Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2
Cellular Signalling García Lopez MA, Aguado Martínez A, Lamaze C, Martínez-A C & Fischer T . The magnitude and duration of G protein-coupled receptor (GPCR) signals are regulated through desensitization mechanisms. In leukocytes, ligand binding to...
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Coronavirus nucleocapsid protein facilitates template switching and is required for efficient transcription
Journal of Virological Methods Zúñiga S, Cruz JL, Sola I, Mateos-Gómez PA, Palacio L & Enjuanes L . Purified nucleocapsid protein (N protein) from transmissible gastroenteritis virus (TGEV) enhanced hammerhead ribozyme self-cleavage and favored nucleic...
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Detection of porcine torovirus by real time RT-PCR in piglets from a Spanish farm
Journal of Virological Methods Pignatelli J, Jiménez M, Grau-Roma L & Rodríguez D Toroviruses are enteric viruses belonging to the Nidovirales order that infect different animal species and humans. The lack of i n vitro culture systems for toroviruses,...
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The Crc global regulator binds to an unpaired A-rich motif at the Pseudomonas putida alkS mRNA coding sequence and inhibits translation initiation
Nucleic Acid Research Moreno R, Marzi S, Romby P & Rojo F Crc is a key global translational regulator in Pseudomonads that orchestrates the hierarchy of induction of several catabolic pathways for amino acids, sugars, hydrocarbons or aromatic...
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Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle
Proceedings of the National Academy of Sciences Guerrero AA, Gamero MC, Trachana V, Fütterer A, Pacios-Bras C, Panadero Díaz-Concha N, Cigudosa JC, Martínez-A C & van Wely KH. Most carcinomas present some form of chromosome instability in combination...
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A high-density collection of EMS-induced mutations for TILLING in Landsberg erecta genetic background of Arabidopsis
BMC Plant Biology Martín B, Ramiro M, Martínez-Zapater JM & Alonso-Blanco C Arabidopsis thaliana is the main model species for plant molecular genetics studies and world-wide efforts are devoted to identify the function of all its genes. To this end,...
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Hepatitis C and evasion of the interferon system: a PKR paradigm
Cell Host & Microbe Esteban M Hepatitis C virus (HCV) is resistant to the antiviral cytokine type I interferon, representing a major clinical problem. Garaigorta and Chisari (2009) reveal that HCV uses the activation of the ds-RNA-dependent protein...
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Effect of the herbicide glyphosate on glyphosate-tolerant maize rhizobacterial communities: a comparison with pre-emergency applied herbicide consisting of a combination of acetochlor and terbuthylazine
Environmental Microbiology Barriuso J, Marín S & Mellado RP A comparison was made of the effect of glyphosate (Roundup((R))Plus), a post-emergency applied herbicide, and of Harness((R))GTZ, a pre-emergency applied herbicide, on the rhizobacterial...
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Candida albicans {beta}-glucan exposure is controlled by the fungal CEK1-mediated MAPK pathway modulating immune responses triggered through Dectin-1.
Infection and Immunity Galán-Díez M, Arana DM, Serrano-Gómez D, Kremer L , Casasnovas JM, Ortega M, Cuesta-Domínguez A, Corbí AL, Pla J, & Fernández-Ruiz E Innate immunity to Candida albicans depends upon recognition of molecular patterns on the fungal...
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Relevance of Proteomics Standards for the ProteoRed Spanish Organization
Journal of Proteomics Martinez-Bartolome S, Blanco F & Albar JP ProteoRed, a Spanish Initiative in the field of proteomics, is reaching international standards. Here we present ProteoRed as an example of collaborative initiative in the field of...
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Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
Genes & Development Sabio G , Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK & Davis RJ. The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene...
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Plant vacuoles: where did they come from and where are they heading?
Current Opinion in Plant Biology Zouhar J & Rojo E Genetic and technical advances of the past few years have allowed us to test some of the vacuolar trafficking and vacuole biogenesis models that had been previously proposed mainly on the basis of...
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Evaluation of isotope-coded protein labeling (ICPL) in the quantitative analysis of complex proteomes
Talanta Paradela A, Marcilla M, Navajas R, Ferreira L, Ramos-Fernandez A, Fernández M, Mariscotti JF, García-del Portillo F & Albar JP An evaluation of the ICPL (isotope-coded protein labeling) non-isobaric labeling technique was performed using two...