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The JA-pathway MYC transcription factors regulate photomorphogenic responses by targeting HY5 gene expression.
Plant J. 2019 Nov 21. Ortigosa A, Fonseca S, Franco-Zorrilla JM, Fernandez-Calvo P, Zander M, Lewsey MG, García-Casado G, Fernández-Barbero 1, Ecker JR, Solano R. Abstract Jasmonates are key regulators of the balance between defense and growth in...
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SEVA 3.0: an update of the Standard European Vector Architecture for enabling portability of genetic constructs among diverse bacterial hosts.
Nucleic Acids Res. 2019 Nov 19. pii: gkz1024. Martínez-García E, Goñi-Moreno A, Bartley B, McLaughlin J, Sánchez-Sampedro L, Pascual Del Pozo H, Prieto Hernández C, Marletta AS, De Lucrezia D, Sánchez-Fernández G, Fraile S, de Lorenzo V. Abstract The...
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Taming out-of-equilibrium dynamics on interconnected networks
Nat Commun. 2019 Nov 22;10(1):5314. Buldú JM, Pablo-Martí F, Aguirre J. Abstract A wide variety of social, biological or technological systems can be described as processes taking place on networked structures in continuous interaction with other...
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DeepRes: a new deep-learning- and aspect-based local resolution method for electron-microscopy maps.
IUCrJ. 2019 Sep 18;6(Pt 6):1054-1063. Ramírez-Aportela E, Mota J, Conesa P, Carazo JM, Sorzano COS. Abstract In this article, a method is presented to estimate a new local quality measure for 3D cryoEM maps that adopts the form of a 'local resolution'...
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Arabidopsis CRL4 Complexes: Surveying Chromatin States and Gene Expression
Front Plant Sci. 2019 Sep 17;10:1095. eCollection 2019. Fonseca S, Rubio V. Abstract CULLIN4 (CUL4) RING ligase (CRL4) complexes contain a CUL4 scaffold protein, associated to RBX1 and to DDB1 proteins and have traditionally been associated to protein...
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Transient callosal projections of L4 neurons are eliminated for the acquisition of local connectivity
Nature Communications volume 10, Article number: 4549 (2019) S. De León Reyes, S. Mederos, I. Varela, L. A. Weiss, G. Perea, M. J. Galazo & M. Nieto Abstract Interhemispheric axons of the corpus callosum (CC) facilitate the higher order functions of...
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Identification of Domains and Factors Involved in MINIYO Nuclear Import
Front Plant Sci. 2019 Sep 5;10:1044. eCollection 2019. Contreras R, Kallemi P, González-García MP, Lazarova A, Sánchez-Serrano JJ, Sanmartín M, Rojo E. Abstract The transition of stem cells from self-renewal into differentiation is tightly regulated to...
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The viral replication organelles within cells studied by electron microscopy.
Adv Virus Res. 2019;105:1-33. Sachse M, Fernández de Castro I, Tenorio R, Risco C. Abstract Transmission electron microscopy (TEM) has been crucial to study viral infections. As a result of recent advances in light and electron microscopy, we are...
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Complex genetic and epigenetic regulation deviates gene expression from a unifying global transcriptional program
PLoS Comput Biol. 2019 Sep 17;15(9):e1007353. Chagoyen M, Poyatos JF. Abstract Environmental or genetic perturbations lead to gene expression changes. While most analyses of these changes emphasize the presence of qualitative differences on just a few...
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Automatic local resolution-based sharpening of cryo-EM maps
Bioinformatics. 2019 Aug 26. pii: btz671. Ramírez-Aportela E, Vilas J, Glukhova A, Melero R, Conesa P, Martínez M, Maluenda D, Mota J, Jiménez A, Vargas J, Marabini R, Sexton PM, Carazo JM, Oscar C, Sorzano S. Abstract MOTIVATION: Recent technological...
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A nanobody targeting the translocated intimin receptor inhibits the attachment of enterohemorrhagic E. coli to human colonic mucosa.
PLoS Pathog. 2019 Aug 29;15(8):e1008031. Ruano-Gallego D, Yara DA, Di Ianni L, Frankel G, Schüller S, Fernández LA. Abstract Enterohemorrhagic E. coli (EHEC) is a human intestinal pathogen that causes hemorrhagic colitis and hemolytic uremic syndrome....
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Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication.
MBio. 2019 Aug 27;10(4). pii: e01839-19. DeDiego ML, Nogales A, Martinez-Sobrido L, Topham DJ. Abstract Using multiple viral systems, and performing silencing approaches, overexpression approaches, and experiments in knockout cells, we report, for the...
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Atomic structure of the Epstein-Barr virus portal.
Nat Commun. 2019 Aug 29;10(1):3891. Machón C Fàbrega-Ferrer M, Zhou D, Cuervo A, Carrascosa JL, Stuart DI, Coll M Abstract Herpesviridae is a vast family of enveloped DNA viruses that includes eight distinct human pathogens, responsible for diseases...
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Defining and combating antibiotic resistance from One Health and Global Health perspectives
Nat Microbiol. 2019 Sep;4(9):1432-1442. Hernando-Amado S, Coque TM, Baquero F, Martínez JL. Abstract Several interconnected human, animal and environmental habitats can contribute to the emergence, evolution and spread of antibiotic resistance, and the...
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Structures of T7 bacteriophage portal and tail suggest a viral DNA retention and ejection mechanism
Nat Commun. 2019 Aug 20;10(1):3746. Cuervo A, Fàbrega-Ferrer M2 Machón C, Conesa JJ, Fernández FJ, Pérez-Luque R, Pérez-Ruiz M, Pous J, Vega MC, Carrascosa JL, Coll M. Abstract Double-stranded DNA bacteriophages package their genome at high pressure...
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Microdiversity ensures the maintenance of functional microbial communities under changing environmental conditions
The ISME Journal (16/8/2019) Natalia García-García, Javier Tamames, Alexandra M. Linz, Carlos Pedrós-Alió & Fernando Puente-Sánchez Abstract Microdiversity can lead to different ecotypes within the same species. These are assumed to provide stability...
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Adenovirus major core protein condenses DNA in clusters and bundles, modulating genome release and capsid internal pressure.
Nucleic Acids Res. 2019 Aug 9. Martín-González N, Hernando-Pérez M, Condezo GN, Pérez-Illana M, Šiber A, Reguera D, Ostapchuk P, Hearing P6, San Martín C, de Pablo PJ. Abstract Some viruses package dsDNA together with large amounts of positively...
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Jasmonate-related MYC Transcription Factors are Functionally Conserved in Marchantia polymorpha
Plant Cell. 2019 Aug 7. pii: tpc.00974.2018 Peñuelas M, Monte I, Schweizer F, Vallat A, Reymond P, García-Casado G, Franco-Zorrilla JM, Solano R. Abstract Jasmonoyl-isoleucine regulates plant immunity, growth and development in vascular plants by...
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Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes.
J Nanobiotechnology. 2019 Aug 6;17(1):87 Sanz-Ortega L, Portilla Y, Pérez-Yagüe , Barber DF. Abstract BACKGROUND: Adoptive T cell-transfer (ATC) therapy is a highly promising cancer-treatment approach. However, in vivo-administered T cells tend to...
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Impaired control of multiple viral infections in a family with complete IRF9 deficiency
J Allergy Clin Immunol. 2019 Jul;144(1):309-312.e10 Bravo García-Morato M, Calvo Apalategi A, Bravo-Gallego LY, Blázquez Moreno A, Simón-Fuentes M, Garmendia JV, Méndez Echevarría A, Del Rosal Rabes T, Domínguez-Soto Á, López-Granados E, Reyburn HT,...