7 June 2013
THE WORKSHOP: The divisome is an assembly of proteins involved in bacterial division. Some of its components, as FtsA and FtsZ, share structural and functional homologies with cytoskeletal proteins. Procedures to reconstruct divisomes in the test tube provide further insights on division and supply new discovery platforms to find new antibiotics.
The purpose of the workshop is to discuss the advances in the study of bacterial division.
KEYNOTE SPEAKER: From his postdoctoral at the University of Edinburgh to his present position at the University of Kansas Medical School, Professor Joe Lutkenhaus pioneering work has been crucial for the discovery and study of divisome components. He has received several academic recognitions, among them the prestigious Louisa Gross Horwitz Prize in 2012.
THE PROGRAMME: We have gathered Spanish microbiologists working on bacterial cell division and some investigators whose work, coming from fields different from microbiology, provide important advances to study bacterial division in the light of novel synthetic biology approaches.
VENUE: At the main CNB lecture room. C/ Darwin nº3. 28049 Madrid. Tel: +34 91 585 45 00
Attendance is free but room capacity is limited.
ORGANIZATION: Miguel Vicente (scientific) and Moira Torrent (technical)
WORKSHOP PROGRAMME (pdf)
10:00 - 10:30: José M. Valpuesta (CNB, Madrid) The folding pathway of actin and tubulin mediated by an assembly line of molecular chaperones
10:30 - 11:00: Luis M. Liz-Marzán (CIC biomaGUNE) Nanoplasmonic Biodetection
11:00 - 11:30: Miguel A. de Pedro (CBMSO, Madrid) Cell wall elongation and septation: Who leads whom?
11:30 - 12:00: Juan Ayala (CBMSO, Madrid) Endopeptidases and carboxypeptidases in bacterial cell cycle. How many and for what purpose?
12:00 -12:30 COFFEE BREAK
12:30 - 13:15: Joe Lutkenhaus (U. Kansas) Min system and the Z ring
13:15 - 13:45: Jesús Mingorance (Hospital La Paz, Madrid) FtsA, bacterial division and the quest for a role
14:00 - 15:30 LUNCH
15:30 - 16:00: Marisela Vélez (ICP, Madrid) Looking at individual FtsZ filaments on surfaces in solution: what we have learned so far
16:00 - 16:30: Germán Rivas (CIB, Madrid) Macromolecular interactions of FtsZ: from physical biochemistry to reconstructing minimal divisomes in cell-like environments
16:30 - 17:00: José M. Andreu (CIB, Madrid) Targeting bacterial cell division protein FtsZ with small molecules
17:00 - 17:30: Paulino Gómez-Puertas (CBMSO, Madrid) In silico design of new antimicrobial compounds directed against FtsZ
17:30 - 18:00: Francisco Monroy (U. Complutense, Madrid) Membrane mechanics of bacterial division: a connection to Z ring mechanistic
18:00 - 18:30: Miguel Vicente (CNB, Madrid) Zipping the Z